The synthesis and biological activity of substituted 2,6-diaminopyridines

Crystal structure of bis[4-(dimethylamino)pyridinium] aquabis(oxalato)oxidovanadate(IV) dihydrate

“…Because of the great importance of vanadium as an effective metal antitumor agent (Evangelou, 2002) and the vanadyl antidiabetic factor via its manifested insulin-mimetic activity (Goc, 2006), the coordination chemistry of this element has received much attention over the past years through the design and synthesis of organic-inorganic hybrid salts and the investigation of their solution chemistry. In addition to that, the use of pyridine and its derivatives in those hybrid materials may also provide biological activity as reported by Markees et al (1968). Many compounds containing the vanadyl V O group combined with oxalate ligands have been isolated as mononuclear (Lin et al, 2004;Aghabozorg et al, 2007;Oughtred et al, 1976) or dinuclear (Zheng et al, 1998) compounds.…”

Synthesis and Applications of Asymmetric Catalysis Using Chiral Ligands Containing Quinoline Motifs

“…Catalytic asymmetric C–C bond-forming reactions provide one of the most efficient methods to synthesize chiral molecules, and a range of pyridine and quinoline-based chiral catalysts have been developed in the past two decades, finding a wide range of applications. 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31…”

“…Quinolines and their derivatives have been labeled as ‘privileged scaffolds’ owing to their prevalent existence in natural and synthetic molecules that exhibit notable applications in pharmacological, agrochemical, and electronic industries (Figure 1 ). 14 15 16 17 18 19 20 21 22 23 24…”

Potent Triazolopyridine Myeloperoxidase Inhibitors

“…Limitations with functional group tolerance and late-stage diversification drove the development of a third synthetic route (Scheme ). Known diamine 10 was reacted with 4-chlorobenzenediazonium chloride to form diazene 11 . Cleavage of the diazene bond with zinc to afford the diamine, followed by cyclization with isoamyl nitrite, formed compound 2 in high yield.…”