The Synthesis and Characterization of Cycloalkoxy-Linear Phosphazenes

Abstract

The reactions of N-dichlorophosphoryl-P-trichlorophosphazene, Cl 3 P N P(O)Cl 2 with the sodium salts of cyclopentanol, cyclohexanol, 4-methylcyclohexanol, 3-methylcyclohexanol, 3-methylcyclopenta-nol are discussed. Pentacycloalkoxy-substituted phosphazenes were obtained from cyclopentanol, 4-methylcyclohexanol, 3-methylcyclohexanol, 3-methylcyclopentanol. Tetrasubstituted derivative also was obtained from cyclohexanol at the same conditions. The structure of products was defined by IR, 1 H, 13 C, 31 P NMR, and mass spectroscopy.The cyclo-and poly-phosphazenes are probably the best known and most intensively studied phosphorus-nitrogen compounds because they are more stable than monophosphazenes. 1,2 Although there are many publications about cyclo-and polyphosphazenes, 3−26 the number is limited for linear phosphazenes because the short-chain species are generally difficult to synthesize, isolate, and study. However, phosphazenes possess a number of characteristics such as the using of drug components for chemotherapeutic applications and antibacterial activity. 27−29 These compounds are used in the structure of medical implants and drug delivery systems. N-di(alkoxy)phosphoryl-P-tri(alkoxy)monophosphazene, especially those with different alkyl groups are biologically active compounds. 30 N-dichlorophosphoryl-P-trichlorophosphazene 1, Cl 3 P N P(O)Cl 2 , which is the short-chain linear phosphazene, is a very sensitive

Synthesis, Characterization, and Biological–Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups

“…The literature contains reports on the synthesis of different linear, cyclic, or poly‐phosphazenes 18–28. The synthesis and different reactions of phosphazenes containing 2,2′‐dioxybiphenyl groups are reported 29, 30.…”

Synthesis, thermal property and hydrolytic degradation of a novel star-shaped hexa[p-(carbonylglycinomethylester)phenoxy]cyclotriphosphazene

“…Thermal stability studies were carried out using a Perkin-Elmer TGA Pyris 1 analyzer (Perkin-Elmer Instrument Co., USA) at 10 …”

“…Cyclotriphosphazene derivatives, substituted with aziridine groups, and polyphosphazeneplatinum (Ⅱ) conjugates, were investigated as biomedical products due to their strong antitumor activity [8,9] . Antimicrobial and biological effects of some phosphazenes on bacterial and yeast cells have been also studied [10][11][12] . On the other hand, it is known that phosphorus-nitrogen compounds are effective flame retardants for fibre materials [13] .…”

Synthesis of oxime bearing cyclophosphazenes and their reactions with alkyl and acyl halides

“…On the other hand, it is known that phosphorus and nitrogen compounds are effective flame retardants for fiber materials [14]. The literature contains reports on the synthesis of different linear, cyclic, or polyphosphazenes [15][16][17][18][19][20][21][22][23][24][25]. There are also a large number of literature reports on reactions of the functional groups on phosphazene substituents [9,[26][27][28][29][30].…”