The synthesis and characterization of targeted delivery curcumin using chitosan-magnetite-reduced graphene oxide as nano-carrier

Kazemi, Seyed Morteza; Pourmadadi, Mehrab; Yazdian, Fatemeh; Ghadami, Azam

doi:10.1016/j.ijbiomac.2021.06.184

Cited by 86 publications

(27 citation statements)

References 54 publications

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“…In order to decrease γAl toxicity, a biocompatible biopolymer (Ch) was used, which improved the cell viability and pH sensitivity of the developed nano-carriers via surface functionalization of the drug-loaded nanoparticles. In addition, double emulsion methods and span 80 as a surfactant were used to increase the stability and uniformity of the nanocarriers and to prevent the precipitation of the nanoparticles during delivery through the body [ 68 , 128 ]. In contrast, based on the MMT assay, 4.8 μg.ml −1 of the free drug led to IC50 on the MCF-7 cell line (more than 50% cell death) [ 126 ], which is consistent with our study.…”

Section: Resultsmentioning

confidence: 99%

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

et al. 2022

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Today, cancer treatment is an important issue in the medical world due to the challenges and side effects of ongoing treatment procedures. Current methods can be replaced with targeted nano-drug delivery systems to overcome such side effects. In the present work, an intelligent nano-system consisting of Chitosan (Ch)/Gamma alumina (γAl)/Fe3O4 and 5-Fluorouracil (5-FU) was synthesized and designed for the first time in order to influence the Michigan Cancer Foundation-7 (MCF-7) cell line in the treatment of breast cancer. Physico-chemical characterization of the nanocarriers was carried out using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), dynamic light scattering (DLS), and scanning electron microscopy (SEM). SEM analysis revealed smooth and homogeneous spherical nanoparticles. The high stability of the nanoparticles and their narrow size distribution was confirmed by DLS. The results of the loading study demonstrated that these nano-systems cause controlled, stable, and pH-sensitive release in cancerous environments with an inactive targeting mechanism. Finally, the results of MTT and flow cytometry tests indicated that this nano-system increased the rate of apoptosis induction on cancerous masses and could be an effective alternative to current treatments.

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Section: Resultsmentioning

confidence: 99%

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

et al. 2022

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“…The physical and chemical properties of graphene and its derivatives (such as reduced graphene oxide [RGO]) include high sensitivity, remarkable selectivity and stability, low overpotential, wide potential window, minimal capacitive current, and outstanding electrocatalytic activity [47,48] various other fascinating properties such as considerable specific surface area, excellent electrical conductivity and transparency, superior mechanical strength and durability, strong ambipolar electrical field effect, good thermal conductivity, and outstanding electronic properties [49,50]. The hybridization of graphene and metal nanoparticles leads to the nanocomposite with excellent surface area and improved the kinesis of charge carriers as well as firm electron transfer kinetics [46,51,52]. Magnetite (Fe 3 O 4 ) nanoparticles are known magnetic materials that have been used increasingly in the biosensor field mainly because of their high surface area, high biocompatibility, low toxicity, easy preparation, and high adsorption ability [53].…”

Section: Introductionmentioning

confidence: 99%

“…It offers various other fascinating properties such as considerable specific surface area, excellent electrical conductivity and transparency, superior mechanical strength and durability, strong ambipolar electrical field effect, good thermal conductivity, and outstanding electronic properties [49, 50]. The hybridization of graphene and metal nanoparticles leads to the nanocomposite with excellent surface area and improved the kinesis of charge carriers as well as firm electron transfer kinetics [46, 51, 52].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Au/Fe₃O₄/RGO based aptasensor for measurement of miRNA‐128, a biomarker for acute lymphoblastic leukemia (ALL)

Dinani

Pourmadadi

Yazdian

et al. 2022

Engineering in Life Sciences

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Due to their high sensitivity, simplicity, portability, self‐contained, and low cost, the development of electrochemical biosensors is a beneficial way to diagnose and anticipate many types of cancers. An electrochemical nanocomposite‐based aptasensor is fabricated for the determination of miRNA‐128 concentration as the acute lymphoblastic leukemia (ALL) biomarker for the first time. The aptamer chains were immobilized on the surface of the glassy carbon electrode (GCE) through gold nanoparticles/magnetite/reduced graphene oxide (AuNPs/Fe3O4/RGO). Fast Fourier transform infrared (FTIR), X‐ray diffraction (XRD), vibrating sample magnetometer (VSM), and transmission electron microscopy (TEM) were used to characterize synthesized nanomaterials. Cyclic voltammetry (CV), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS) were used to characterize the modified GCE in both label‐free and labeled methods. The results indicate that the modified working electrode has high selectivity and for miRNA‐128 over other biomolecules. The hexacyanoferrate redox system typically operated at around 0.3 V (vs. Ag/AgCl), and the methylene blue redox system ran at about 0 V, were used as an electrochemical probe. The detection limit and linear detection range for hexacyanoferrate and methylene blue are 0.05346 fM, 0.1–0.9 fM, and 0.005483 fM, 0.01–0.09 fM, respectively. The stability and diffusion control analyses were performed as well. In both label‐free and labeled methods, the modified electron showed high selectivity for miRNA‐128. The use of methylene blue as a safer redox mediator caused miRNA‐128 to be detected with greater accuracy at low potentials in PBS media. The findings also show the substantial improvement in detection limit and linearity by using reduced graphene oxide‐magnetite‐gold nanoparticles that can be verified by comparing with previous studies on the detection of other miRNAs.

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“…Furthermore, an absorption peak at 1710 cm −1 is related to C=O functional groups that can react with the functional groups of other biomaterials, such as aptamer chains. The synthesis and characterization of targeted delivery using chitosan-magnetite-reduced graphene oxide is possible as nanocarrier ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Detection of Microorganisms Using Graphene-Based Nanobiosensors

Pourmadadi

Yazdian

Hojjati

2021

Food Technol. Biotechnol. (Online)

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Having an insight into graphene and graphene derivatives such as graphene oxide, reduced graphene oxide, and graphene quantum dots structures is necessary since it can help scientists to suspect the possible properties and features that using these carbon materials in preparation of a nanocomposite could bring out. In recent years, graphene and its derivatives are attractive with extensive applications in biosensors due to fascinating properties, such as high surface area, optical and magnetic properties, and high elasticity for the detection of microorganisms can be modified with some other materials such as macromolecules, oxide metals, and metals to improve the electrochemical behavior of the biosensor, and also can be modified with some other materials such as macromolecules, oxide metals, and metals to improve the electrochemical behavior of the biosensor. In this review paper, biosensors design strategies based on graphene and its derivatives (graphene-based nanocomposites in biosensors) are introduced. Then their application for the detection of microorganisms including Prions, Viroids, viral and bacterial cells as well as fungi, protozoa, microbial toxins, and even microbial-derived antibiotics are reviewed.

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The synthesis and characterization of targeted delivery curcumin using chitosan-magnetite-reduced graphene oxide as nano-carrier

Cited by 86 publications

References 54 publications

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

Fabrication of Au/Fe₃O₄/RGO based aptasensor for measurement of miRNA‐128, a biomarker for acute lymphoblastic leukemia (ALL)

Detection of Microorganisms Using Graphene-Based Nanobiosensors

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The synthesis and characterization of targeted delivery curcumin using chitosan-magnetite-reduced graphene oxide as nano-carrier

Cited by 86 publications

References 54 publications

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

Chitosan/Gamma-Alumina/Fe3O4@5-FU Nanostructures as Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity

Fabrication of Au/Fe3O4/RGO based aptasensor for measurement of miRNA‐128, a biomarker for acute lymphoblastic leukemia (ALL)

Detection of Microorganisms Using Graphene-Based Nanobiosensors

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Fabrication of Au/Fe₃O₄/RGO based aptasensor for measurement of miRNA‐128, a biomarker for acute lymphoblastic leukemia (ALL)