The synthesis of chitosan-based silver nanoparticles and their antibacterial activity

Wei, Dongwei; Sun, Wei; Qian, Weiping; Yongzhong, Ye; Ma, Xiaoyuan

doi:10.1016/j.carres.2009.09.001

Cited by 592 publications

(376 citation statements)

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“…The PVP-Ag nanocomposite spectra of all samples exhibited a single characteristic surface plasmon resonance (SPR) absorption band around 410 nm which indicates the formation of AgNPs. The appearance of a single absorption band in the range 400-450 nm suggests that the AgNPs is formed in spherical shape [34][35][36][37]. It also can be noticed that the intensity of SPR band of AgNPs increases with increasing the volume of AgNO 3 solution (Fig.…”

Section: Ultraviolet-visible Spectroscopymentioning

confidence: 86%

Assessment of in situ-Prepared Polyvinylpyrrolidone-Silver Nanocomposite for Antimicrobial Applications

et al. 2017

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Polyvinylpyrrolidone (PVP) is employed in several potential applications, relying of its special chemical and physical properties in addition to its low toxicity and biocompatibility. The aim of this work is to prepare polyvinylpyrrolidone-silver (PVP-Ag) nanocomposite with high inhibiting effect on the microbial growth and low cytotoxicity. In situ prepared small stable spherical silver nanoparticles, with narrow range particle size distribution, were obtained by easy, economical and rapid chemical reduction method. Silver ions were reduced to silver nanoparticles using low amount of sodium borohydride (NaBH4) as a strong reducing agent. PVP-Ag nanocomposite was prepared using PVP as a stabilizing and capping agent. Formation of the spherical silver nanoparticles with mean particle size 5 nm was confirmed by ultraviolet-visible spectroscopy, high resolution transmission electron microscopy, and dynamic light scattering. The inhibiting growth effect of the nanocomposite toward Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Pseudomonas aeruginosa), and yeast fungus (Candida albicans) were studied. The cytotoxicity of the nanocomposite against BJ1 normal skin fibroblast cell line was tested. Results of this work presented perfect antimicrobial activity of the PVP-Ag nanocomposite towards bacteria and fungi with low cytotoxicity, which may lead to promising applications in skin wound healing.

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Section: Ultraviolet-visible Spectroscopymentioning

confidence: 86%

Assessment of in situ-Prepared Polyvinylpyrrolidone-Silver Nanocomposite for Antimicrobial Applications

et al. 2017

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] For example, anchoring AgNPs to methacrylic acid copolymer beads has proven to be highly effective against a few bacteria. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, the antimicrobial properties of all reported AgNP-encapsulated composites were tested for only a very few bacteria, and, more importantly, their biocompatibility has not been determined. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, the antimicrobial properties of all reported AgNP-encapsulated composites were tested for only a very few bacteria, and, more importantly, their biocompatibility has not been determined. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] The lack of the latter information is critical because toxicity of AgNPs is known to be dependent on the concentration, and without information on the biocompatibility, the application of such a composite is rather limited. It is, therefore, of particular importance to develop a novel method to anchor AgNPs to composite biopolymers such as cellulose (CEL) and keratin (KER) and thoroughly and systematically investigate the antimicrobial and biocompatibility of the composites.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22][23][24][25][26][27][28] Furthermore, KER is known to possess advantages for wound care, tissue reconstruction, cell seeding and diffusion, and drug delivery. [11][12][13][14][15][16][17][18][19][20] Unfortunately, in spite of its unique properties, KER has relatively poor mechanical properties, and as a consequence, it was not possible to fully exploit the unique properties of KER for various applications. [19][20][21][22][23][24][25][26][27][28] To increase the structural strength of KER-based materials, attempts have been made to cross-link KER chains with a cross-linking agent or introduce functional groups to its amino acid residues via chemical reaction(s).…”

Section: Introductionmentioning

confidence: 99%

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One-Pot Synthesis of Biocompatible Silver Nanoparticle Composites from Cellulose and Keratin: Characterization and Antimicrobial Activity

Tran

Prosenc

Franko

et al. 2016

ACS Appl. Mater. Interfaces

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A novel, simple method was developed to synthesize biocompatible composites containing 50% cellulose (CEL) and 50% keratin (KER) and silver in the form of either ionic (Ag + ) or Ag 0 nanoparticles (Ag + NPs or Ag 0 NPs). In this method, butylmethylimmidazolium chloride ([BMIm + Cl -]), a simple ionic liquid, was used as the sole solvent and silver chloride was added to the [BMIm + Cl -] solution of [CEL+KER] during the dissolution process. The silver in the composites can be maintained as ionic silver (Ag + ) or completely converted to metallic silver (Ag 0 ) by reducing it with NaBH4. The results of spectroscopy [Fourier transform infrared and X-ray diffraction (XRD)] and imaging [scanning electron microscopy (SEM)] measurements confirm that CEL and KER remain chemically intact and homogeneously distributed in the composites. Powder XRD and SEM results show that the silver in the [CEL+KER+Ag + ] and [CEL+KER+Ag 0 ] composites is homogeneously distributed throughout the composites in either Ag + (in the form of AgClNPs) or Ag 0 NPs form with sizes of 27 ± 2 or 9 ± 1 nm, respectively. Both composites were found to exhibit excellent antibacterial activity against many bacteria including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, methicillin-resistant S. aureus (MRSA), and vancomycin-resistant Enterococus faecalis (VRE). The antibacterial activity of both composites increases with the Ag + or Ag 0 content in the composites. More importantly, for the same bacteria and the same silver content, the [CEL+KER+AgClNPs] composite is relatively more toxic than [CEL+KER+Ag 0 NPs] composite. Experimental results confirm that there was hardly any Ag 0 NPs release from the [CEL+KER+Ag 0 NPs] composite, and hence its antimicrobial activity and NOT THE PUBLISHED VERSION; this is the author's final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation at the bottom of the page. Vol 8, No. 50 (2016): pg. 34791-34801. DOI. This article is © American Chemical Society and permission has been granted for this version to appear in e-Publications@Marquette. American Chemical Society does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from American Chemical Society. ACS Applied materials & Interfaces,3 biocompatibility is due not to any released Ag 0 NPs but rather entirely to the Ag 0 NPs embedded in the composite. Both AgClNPs and Ag 0 NPs were found to be toxic to human fibroblasts at higher concentration (>0.72 mmol), and for the same silver content, the [CEL+KER+AgClNPs] composite is relatively more toxic than the [CEL+KER+Ag 0 NPs] composite. As expected, by lowering the Ag 0 NPs concentration to 0.48 mmol or less, the [CEL+KER+Ag 0 NPs] composite can be made biocompatible while still retaining its antimicrobial activity against bacteria such as E. coli, S. aureus, P. aeruginosa, MRSA, and VRE. These results, together with our previous finding that [CEL+KER] composites can ...

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“…Since NPs modified with different coatings such as polyethyleneimines (66), chitosan (48), glucosamine (67) and peptides (personal unpublished data)generally showed an increased antibacterial activity that has been related to the increased uptake as a consequence of a greater binding ability of nanoparticles to bacterial cells, Brown et al (68) functionalised the surface of NPs with ampicillin (NP-AMP). They observed that NP-AMPs had increased biocidal activity compared to NPs.…”

Section: Drug Mechanisms Of Action On Bacteriamentioning

confidence: 99%

Nanomedicine opened new horizons for metal nanoparticles to treat multi-drug resistant organisms

Halawani¹

2016

Int.J.Curr.Microbiol.App.Sci

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The synthesis of chitosan-based silver nanoparticles and their antibacterial activity

Cited by 592 publications

References 31 publications

Assessment of in situ-Prepared Polyvinylpyrrolidone-Silver Nanocomposite for Antimicrobial Applications

Assessment of in situ-Prepared Polyvinylpyrrolidone-Silver Nanocomposite for Antimicrobial Applications

One-Pot Synthesis of Biocompatible Silver Nanoparticle Composites from Cellulose and Keratin: Characterization and Antimicrobial Activity

Nanomedicine opened new horizons for metal nanoparticles to treat multi-drug resistant organisms

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