The synthesis of immunomodulating peptide alloferon, the active principle of antiviral drug allokine-alpha

Sidorova, M. V.; Молокоедов, А. С.; Kudryavtseva, Е. V.; Baldin, M. I.; Frid, D. A.; Овчинников, М. В.; Bespalova, Zh. D.; Бушуев, В. Н.

doi:10.1134/s1068162006020051

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Currently, alloferon-1 is produced by chemical synthesis [47]. Based on synthetic alloferon-1, there is developed an injection able drug form was manufactured under the name Alloying-alpha and aimed at treating recurrent genital herpes and hepatitis B ( [41,48,49]. As compared with acyclovir, the "golden standard" of anti-herpetic drugs, allokin-alpha eliminates herpes eruptions much faster and, which is particularly important, provide the longer remission time.…”

Section: Alloferonsmentioning

confidence: 99%

The immune system of maggots of the blow fly (Calliphora vicina) as a source of medicinal drugs

Chernysh

Gordja

2011

J Evol Biochem Phys

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Studies of cellular and humoral immunity of the blow fly Calliphora vicina maggot revealed three groups of pharmacologically active substances that are perspective for use in medicine: alloferons, allocations, and antimicrobial peptides. Alloferons are the C. vicina peptide family selectively stimulating cytotoxic activity of the natural killer cells, an evolutionary ancient group of immunocompetent cells playing the key role in antiviral and antitumoral immunity of mammals. Alloferons are used in medicine for treatment of herpes viral infections and viral hepatitis B. Allostatins are synthetic peptides combining structural characteristics both of alloferons and of some mammalian immunoactive proteins. Allostatins, like alloferons, stimulate cytotoxic activity of the natural killer cells and interferon production, but, unlike alloferons, have pronounced adjuvant properties, i.e., the ability to enhance immune recognition of alien (non-self) antigens. At present, allostatins are used to enhance resistance of skin and mucous membranes to viral infections; in future, they might find use in immunotherapy of cancer and other diseases. One more group of proteins and peptides of the C. vicina maggot immune response, which are promising for use in medicine, serve antimicrobial peptides. The study of the preparation whose composition inclusdes defensins, cecropins, diptericins, and proline-rich peptides of C. vicina show that this type of drugs has great potential for treatment and prevention of antibiotic-resistant infections.

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Section: Alloferonsmentioning

confidence: 99%

The immune system of maggots of the blow fly (Calliphora vicina) as a source of medicinal drugs

Chernysh

Gordja

2011

J Evol Biochem Phys

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“…The peptide was synthesized by "Peptide synthesis ltd" (Moscow) using solid-phase synthesis technique as described [12]. Final purity of the peptide measured by HPLC was over 98%.…”

Section: Alloferon-1mentioning

confidence: 99%

Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model

Chernysh

Kozuharova

Irina

2012

International Immunopharmacology

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The synthesis of immunomodulating peptide alloferon, the active principle of antiviral drug allokine-alpha

Cited by 2 publications

References 6 publications

The immune system of maggots of the blow fly (Calliphora vicina) as a source of medicinal drugs

The immune system of maggots of the blow fly (Calliphora vicina) as a source of medicinal drugs

Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model

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