The Synthesis of Methoxymethyl Derivatives of Boldine: Versatile Protected Precursors of Substituted Boldine Derivatives.

Abstract

Alkaloids U 0600The Synthesis of Methoxymethyl Derivatives of Boldine: Versatile Protected Precursors of Substituted Boldine Derivatives. -(REVECO*, P. G.; ASENCIO, M.; SANGUINETTI, M. E.; THOMET, F. A.; Synth. Commun. 35 (2005) 3, 341-347; Dep. Quim., Univ. Tec. Federico St. Maria, Valparaiso, Chile; Eng.) -H. Toeppel 30-181

Cytotoxic Thiocarbamate Derivatives of Boldine

“…The methanolic leaf extract of Peumus boldus has cytotoxic activity on two human cancer cell lines, whereas boldine itself behaves as an intercalating agent [3,4]. Despite the potential of this natural product, few derivatives of boldine have been prepared [5,6]. This paper focuses on the preparation of two new sulphur derivatives by thiocyanation and the evaluation of their in vitro inhibitory effect on the growth of two breast cancer lines (MDA-MB-231, MCF-7) and one dermal human fibroblast cell line (DHZ) using the sulphorhodamine dye assay.…”