The Synthesis of Pantetheine—Pantethine^1a

Pantethine and Related Forms of the Lactobacillus Bulgaricus Factor (LBF)

“…Equations (5) and (6) Over-all yields of 50 per cent of theory were obtained; details of purification and drying were not given. In a repetition of this preparative route, Wittle et al (16) obtained yields about equal to those given by the azide procedure. …”

“…(IS), and in subsequent full detail by Wittle et al (16). During purification, the sulfhydryl form of the compound, N-(pantotheny1)-2-aminoethariethiol, is oxidized to the corresponding disulfide.…”

“…During purification, the sulfhydryl form of the compound, N-(pantotheny1)-2-aminoethariethiol, is oxidized to the corresponding disulfide. These compounds were named pantetheine anti pantethine, respectively (16,18), and show full activity as LHF for all test organisms so far examined (9, 16,18). Synthescs of pantethine have also been described hy Wieland and Rokelmann Acetamide was used as a catalyst, and the product purified by partition between solvents, by adsorption and elution from Superfiltrol columns, or both.…”

“…Synthesis from P-Mercaptoethylamine and the Azide of Pantothenic Acid (16). Equations (3) ant1 (4) summarize this procedure: The iritermediate hydrazide and azide of paiitothenic acid were riot isolated.…”

“…The condensation has been effected either in alcoholic solution a t room temperature (16) or in the absence of solvent a t 100'. Yields of from 80 to 95 per cent are obtained.…”