The Synthesis of Some Pyridylpyridazines and -pyrimidines¹

Crystal structure of 3,6-di-2-pyridinyl-4-pyridazine carbonitrile, C15H9N5

“…Highly functionalized pyridazine are easily accessible via an inverse Diels-Alder reaction between the 1, 2, 4, 5-tetrazine and a wide variety of acetylenes, whereby the tetrazine acts as the electron de cient diene [4,14]. The synthesis of 3,6-di(2-pyridyl)tetrazine and its utilization in inverse-type DielsAlder reactions was rst described by Butte and Case [5]. In continuation of that work other groups have reported similar cycloadditions to the 3,6-di(2-pyridyl)tetrazine, resulting in monosubstituted octyl, carboxy ethyl or tetrahydropyranyl diethyl ethers of methanol, hexanol and fullerenes [4,15,16].…”

“…The ligand was prepared using the method of Butte and Case [4,5]. 3,6-di(2-pyridyl)tetrazine (1.0 g, 6.8 mmoles) and (1.1 g, 20.73 mmoles) of acrylonitrile were dissolved in 25 mL of toluene.…”

Oxidorhenium(V) and Imidorhenium(V) Complexes of Pyridylpyridazine:Oxygen Atom Transfer, Oxidation and Substitution Involving Oxido, Phosphine Oxide and Phosphine Coordination

“…The concerned ligand 3,6-di(2-pyridyl)pyridazine (dppz, 1) was synthesized using available method 10 . The equimolecular reaction of dppz with ReOCl 3 (PPh 3 ) 2 in stirred benzene solution at room temperature afforded the orange-yellow oxido complex 2 (Eq.…”

Synthesis and Catalytic Water Oxidation Activities of Ruthenium Complexes Containing Neutral Ligands

“…[38] This was subsequently treated with hydrazine in ethanol to form the dihydro base 7, which was further oxidised with nitric acid in acetic acid to afford the tetrazine 8 as a pink solid. [39] Bubbling of acetylene through a solution of 8 in DMF at reflux provided the bis-tridentate ligand 3,6-bis-(4,4'-dimethyl-2,2'-bipyrid-6-yl)pyridazine (L1) as a white solid. [39] The synthesis of L2 is shown in Scheme 4.…”

“…[39] Bubbling of acetylene through a solution of 8 in DMF at reflux provided the bis-tridentate ligand 3,6-bis-(4,4'-dimethyl-2,2'-bipyrid-6-yl)pyridazine (L1) as a white solid. [39] The synthesis of L2 is shown in Scheme 4. The compound 11 could be obtained in a good yield by a procedure similar to that described above.…”