The systemic inflammation-based neutrophil–lymphocyte ratio: Experience in patients with cancer

Guthrie, G.J.K.; Charles, Kellie A.; Roxburgh, Campbell S.D.; Horgan, Paul G.; McMillan, Donald C.; Clarke, Stephen

doi:10.1016/j.critrevonc.2013.03.010

Cited by 1,301 publications

(1,209 citation statements)

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“…[22][23] Components of the differential white cell count including a variety of ratios derived from neutrophils, monocytes and lymphocytes have been of interest, particularly in the setting of clinical oncology. [24][25] However relationships between these ratios, such as the neutrophil lymphocyte ratio (NLR) and lymphocyte monocyte ratio (LMR) and iron status are unclear.…”

Section: Discussionmentioning

confidence: 99%

Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status

McSorley

Jones

McMillan

et al. 2016

Translational Research

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Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status. Translational Research, 176, pp. 119-126. (doi:10.1016Research, 176, pp. 119-126. (doi:10. /j.trsl.2016 This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/120861/

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Section: Discussionmentioning

confidence: 99%

Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status

McSorley

Jones

McMillan

et al. 2016

Translational Research

Self Cite

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“…Increased neutrophil lymphocyte ratio (N/L ratio) values and mean platelet volume (MPV) values are associated with inflammatory diseases (Gasparyan et al, 2011;Guthrie et al, 2013), whereas in the noninflammatory diseases N/L ratio values are in normal range (Olt et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer

Yaylacı¹,

Tosun²,

Şahin³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…Complete blood count and its subtype neutrophil count and neutrophil lymphocyte ratio (NLR) are an indicator of systemic inflammation (Guthrie et al, 2013). …”

Section: Introductionsmentioning

confidence: 99%

“…Breast cancer risk related with proliferative breast disease. Several studies showed that inflammation plays an important role in the development of BPBD and early breast carcinogenesis (Catsburg et al, 2014).Complete blood count and its subtype neutrophil count and neutrophil lymphocyte ratio (NLR) are an indicator of systemic inflammation (Guthrie et al, 2013). …”

mentioning

confidence: 99%

Diagnostic and Prognostic Importance of the Neutrophil Lymphocyte Ratio in Breast Cancer

Özyalvaçlı¹,

Yesil²,

Karğı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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IntroductionsBreast cancer is the most common type of cancer in women and the risk increases with age. As in other tumors the development of breast carcinoma is associated with systemic inflammation. The systemic inflammatory response can change with tumor growth, invasion, angiogenesis and metastasis. İnflammatory markers such as c reactive protein (CRP) and interleukin 6 (IL 6) are increased in breast cancer patients and a have adverse effect on survey (Balta et al., 2013).Benign proliferative breast disease (BPBD) is most common in women who are in their thirties to fifties. Various sizes of cysts, adenosis, hyperplasia with atypia and/or without atypia and apocrine metaplasia can be seen in BPBD on microscopic examination. Despite the strong association between BPBD and breast cancer development, the exact causes of BPBD are still unknown. Hormonal imbalance especially increased estrogen via to progestin is thought to play a role in development of BPBD. Breast cancer risk related with proliferative breast disease. Several studies showed that inflammation plays an important role in the development of BPBD and early breast carcinogenesis (Catsburg et al., 2014).Complete blood count and its subtype neutrophil count and neutrophil lymphocyte ratio (NLR) are an indicator of systemic inflammation (Guthrie et al., 2013). AbstractBackground: The aim of this study was to determine diagnostic and prognostic roles of the neutrophil to lymphocyte ratio (NLR) in breast cancer patients. To date, data are limited on associations of primary breast carcinoma (PBC) and benign proliferative breast disease (BPBD) with preoperative NLR values. Materials and Methods: Our study covered of 120 female patients with PBC and 50 with BPBD. Diagnostic values of NLR were estimated using sensitivity, specificity and areas under receiver operating characteristic curves (AUC). Results: NLR values were significantly higher in the PBC patients than in those with BPBD, with an AUC of 0.668 in the PBC case. The optimal cut-off for NLR was 2.96 and this was validated in the testing set, giving a sensitivity and a specificity of 79.7% and 76.2%, respectively, in PBC patients. Conclusions: Preoperative high NLR is a significant diagnostic predictor of distinction of breast cancer from BPBD and elevated NLR is also an important prognostic marker for primary invasive breast cancer.

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The systemic inflammation-based neutrophil–lymphocyte ratio: Experience in patients with cancer

Cited by 1,301 publications

References 61 publications

Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status

Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status

Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer

Diagnostic and Prognostic Importance of the Neutrophil Lymphocyte Ratio in Breast Cancer

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