The T&gt;A (rs11646213) gene polymorphism of cadherin-13 (CDH13) gene is associated with decreased risk of developing hypertension in Mexican population

Vargas‐Alarcón, Gilberto; Martínez‐Rodríguez, Nancy; Velázquez‐Cruz, Rafael; Pérez-Méndez, Óscar; Posadas-Sánchez, Rosalinda; Posadas‐Romero, Carlos; Peña‐Duque, Marco Antonio; Martínez-Ríos, Marco Antonio; Ramírez-Fuentes, Silvestre; Fragoso, J.M.

doi:10.1016/j.imbio.2016.09.004

Cited by 10 publications

(11 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We focus on the human protein-coding genes genetically associated with CVD annotated by Eupedia (https://www.eupedia.com/genetics/heart_disease_snp.shtml) and by scientific publications [19–22] to investigate the links between miRNAs and the molecular mechanism of CVD. A brief overview of the study is shown in Additional file 1: Figure S1.…”

Section: Resultsmentioning

confidence: 99%

“…Studies have shown that mutations in the three protein-coding genes are associated with CVD. The CDH13 rs4783244 polymorphism confers stronger cardio-protection [21], and the CDH13 rs11646213 polymorphism is associated with risk of developing hypertension [22]. The SLC12A3 mutations produce clinically significant blood pressure reduction and protect from development of hypertension [20, 24].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Three miRNAs cooperate with host genes involved in human cardiovascular disease

2019

View full text Add to dashboard Cite

Background Understanding the roles of miRNAs in cardiovascular disease remains a challenge. Genomic linkage indicates a functional relationship between intronic miRNAs and their host genes. However, few studies have shown functional association between intronic miRNAs and their host coding genes that are genetically associated with cardiovascular disease. Methods In this study, we investigated functional relationship between three protein-coding genes genetically associated with cardiovascular disease, i.e., CDH13, SLC12A3, and CKAP5, and their intronic miRNAs using a data-driven approach. Results We found that the three protein-coding genes functionally interact with targets of their intronic miRNAs, i.e., miR-3182, miR-6863, and miR-5582, in a tissue-specific pattern. The intronic miRNAs preferentially impact important genes for the three host genes in the network, indicating their roles in maintaining the integrity of the interactome where the host genes are involved. Targets of the intronic miRNAs display functional similarity to the host genes. We furthermore present sets of target genes for future investigation on the possible miRNA-target interactions that potentially contribute to cardiovascular diseases. Conclusions Our work provides new insight into the regulatory network of the cardiovascular-associated pathways and opens the possibility for future experimental research. Electronic supplementary material The online version of this article (10.1186/s40246-019-0232-4) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Three miRNAs cooperate with host genes involved in human cardiovascular disease

2019

View full text Add to dashboard Cite

show abstract

“…CDH-13 is abundant in developing and adult brains [21], and has been associated with various psychiatric disorders [22][23][24]. In addition, CDH-13 influences vascular function, and has been associated with vascular disorders such as atherosclerosis and hypertension [25][26][27]. Although CDH-13 is known to regulate cell-cell interactions in the plasma membrane, it also circulates in the blood.…”

Section: Introductionmentioning

confidence: 99%

Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss

Yang

Kabir

Park

et al. 2020

Aging

View full text Add to dashboard Cite

The blood exhibits a dynamic flux of proteins that are secreted by the tissues and cells of the body. To identify novel aging-related circulating proteins, we compared the plasma proteomic profiles of young and old mice using tandem mass spectrometry. The expression of 134 proteins differed between young and old mice. We selected seven proteins that were expressed at higher levels in young mice, and confirmed their plasma expression in immunoassays. The plasma levels of anthrax toxin receptor 2 (ANTXR2), cadherin-13 (CDH-13), scavenger receptor cysteine-rich type 1 protein M130 (CD163), cartilage oligomeric matrix protein (COMP), Dickkopf-related protein 3 (DKK3), periostin, and secretogranin-1 were all confirmed to decrease with age. We then investigated whether any of the secreted proteins influenced bone metabolism and found that CDH-13 inhibited osteoclast differentiation. CDH 13 treatment suppressed the receptor activator of NF-κB ligand (RANKL) signaling pathway in bone marrow-derived macrophages, and intraperitoneal administration of CDH-13 delayed age-related bone loss in the femurs of aged mice. These findings suggest that low plasma CDH-13 expression in aged mice promotes aging-associated osteopenia by facilitating excessive osteoclast formation. Thus, CDH-13 could have therapeutic potential as a protein drug for the prevention of osteopenia.

show abstract

“…Its expression increases in such pathological conditions of vessels, where the endothelial dysfunction develops [13]. The T-cadherin receptor of endothelial and vascular smooth muscle cells is involved in the development of hypertension [14]. Associations of cardiovascular and metabolic diseases with T-Cad gene polymorphism, predominant T-Cad expression in the cardiovascular system, cardioprotection and revascularization of ischemic limbs in the interaction of T-Cad with adiponectin indicate the role of this receptor in the functioning of heart cells and vessels most important [15].…”

Section: Resultsmentioning

confidence: 99%

Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts

et al. 2019

View full text Add to dashboard Cite

Background The strategy of adaptation of the human body in microgravity is largely associated with the plasticity of cardiovascular system regulatory mechanisms. During long-term space flights the changes in the stroke volume of the heart are observed, the heart rate decreases, the phase structure of cardiac cycle is readjusted The purpose of this work was to clarify urine proteome changes associated with the initial condition of the heart rate autonomic regulation mechanisms in cosmonauts who have participated in long space missions. Urine proteome of each cosmonaut was analyzed before and after space flight, depending on the initial parameters characterizing the regulatory mechanisms of the cardiovascular system. Results The proteins cadherin-13, mucin-1, alpha-1 of collagen subunit type VI (COL6A1), hemisentin-1, semenogelin-2, SH3 domain-binding protein, transthyretin and serine proteases inhibitors realize a homeostatic role in individuals with different initial type of the cardiovascular system regulation. The role of significantly changed urine proteins in the cardiovascular homeostasis maintenance is associated with complex processes of atherogenesis, neoangiogenesis, activation of calcium channels, changes in cell adhesion and transmembrane properties, changes in extracellular matrix, participation in protection from oxidative stress and leveling the effects of hypoxia. Therefore, the concentrations of these proteins significantly differ between groups with dominant parasympathetic and sympathetic influences. Conclusion The space flight induced urine proteome changes are significantly different in the groups identified by heart rate autonomic regulation peculiarities before space flight. All these proteins regulate the associated biological processes which affect the stiffness of the vascular wall, blood pressure level, the severity of atherosclerotic changes, the rate and degree of age-related involution of elastin and fibulin, age-related increase in collagen stiffness, genetically determined features of elastin fibers. The increased vascular rigidity (including the aorta) and of myocardium may be regarded as a universal response to various extreme factors. Significant differences in the semi-quantitative analysis of signal proteins between groups with different types of autonomic regulation are explained by a common goal: to ensure optimal adaptation regardless of age and of the genetically determined type of responses to the extreme environmental factors effects. Electronic supplementary material The online version of this article (10.1186/s12918-019-0688-9) contains supplementary material, which is available to authorized users.

show abstract

The T>A (rs11646213) gene polymorphism of cadherin-13 (CDH13) gene is associated with decreased risk of developing hypertension in Mexican population

Cited by 10 publications

References 28 publications

Three miRNAs cooperate with host genes involved in human cardiovascular disease

Three miRNAs cooperate with host genes involved in human cardiovascular disease

Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss

Urine proteome changes associated with autonomic regulation of heart rate in cosmonauts

Contact Info

Product

Resources

About