The target cell in the chemical induction of carcinomas in mouse submandibular gland

Wigley, Caroline B.; Carbonell, A. W.

doi:10.1016/0014-2964(76)90024-4

Cited by 19 publications

(9 citation statements)

References 8 publications

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“…In addition, it was considered important that compounds were tested in as many different systems as possible to assess their carcinogenic potential in a wide range of tissues. Previously, dimethylbenz(a)anthracene (DMBA) had been shown to induce submandibular salivary gland tumours readily, particularly squamous carcinomas, when it was injected directly into the glands of adult mice (Wigley and Carbonell, 1976). This study confirmed earlier reports that the epithelium of this gland was particularly susceptible to hydrocarbon carcinogenesis (Rusch et al, 1942).…”

Section: Benzo(a)pyrene (B(a)p;supporting

confidence: 83%

“…This indicates that salivary-gland cells are not completely refractory to carcinogenesis by this compouind. Fewer carcinomas compared to sarcomas were induced by B(a)P in this study than were found after IDMBA injection (Wigley and Carbonell, 1976) or in a recent study using 2 mg B(a)P in a larger group of C57BL Icrf at mice (WVigley, unpublished). B(a)P was shown, however, to be a good carcinogen in the salivary-gland system, although the average latent period of tumour development is rather longer than previously found for DMBA.…”

Section: Resultssupporting

confidence: 42%

“…This dose was given as 0 05 ml of an emulsion in watersoluble KY jelly (Johnson and Johnson Ltd, Slough, Bucks). A more detailed description of the injection technique is given elsewhere (Wigley and Carbonell, 1976). A control group of mice received carrier emulsion only.…”

Section: Methodsmentioning

confidence: 99%

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Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland

Wigley¹,

Amos²,

Brookes³

1978

Br J Cancer

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Summary.-A comparison has been made between the carcinogenic activities of benzo(a)pyrene and the proposed proximate carcinogen, benzo(a)pyrene7,8-dihydrodiol, in the adult C57BL mouse submandibular salivary gland. In preliminary studies using a range of doses, the dihydrodiol was slightly less active than the parent hydrocarbon in this system.There was a difference in the type of tumour induced by the 2 compounds. Benzo(a)pyrene induced tumours of the salivary glands at the site of injection, whereas the dihydrodiol induced malignant lymphosarcomas, particularly of the thymus, which were often metastatic to other organs.Possible reasons for the different sites of action of the 2 compounds are discussed.

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Section: Benzo(a)pyrene (B(a)p;supporting

confidence: 83%

Section: Resultssupporting

confidence: 42%

See 1 more Smart Citation

Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland

Wigley¹,

Amos²,

Brookes³

1978

Br J Cancer

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“…Submandibular glands have been shown to contain biologically active polypeptides such as EGF (epidermal growth factor) and NGF (nerve growth factor) in the granular convoluted tubules (GCT) of submandibular glands (SMGs) in mice and rats (1,6,8,9,10). Ductal epithelia including GCT segments of salivary glands have been proposed as the origin of salivary gland tumors (12,15,18). Specifically, GCT cells have been implicated as a source of neoplastic transformation with positive keratin staining, as has been previously reported (13).…”

mentioning

confidence: 99%

Immunohistochemical detection of keratin proteins in salivary gland ducts of mammals.

Takai

Noda

Sumitomo

et al. 1985

Acta Histochem. Cytochem

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“…Experitnental eateinotnas in salivaty glands are thought to arise ftotn duetal segtiients including the granular convoluted tubule cells. The eells of origin of induced eateinotnas in mouse subtnandibular glands bas been eonsidered to possibly be the granular convoluted tubule eells and striated duets (Wigley & Carbonell 1976), or tbe granular convoluted tubule cells (Takai et al 1984).…”

mentioning

confidence: 99%

Histochemical studies on Concanavalin A‐binding in experimental carcinoma of the mouse submandibular gland

Takai¹,

Kh²,

Hosaka³

et al. 1984

J Oral Pathology Medicine

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The lectin, Concanavalin A(Con A) has been used to loealize speeifie sugar residues (D-glucose, D-tnannose and D-lructose) in premalignant lesions and squatnous-cell carcinomas induced following cryosurgery of the mouse .submandibular gland. The original Con A-horseradish peroxidase (HRP) technique as well as its combination with pcriodate oxidation and subsequent reduction by borohydrate were used to compatc the epithelial elements during submandibular gland carcinogenesis. Granules in the granular convoluted tubule eells which were weakly reactive to the Con A-HRP method were not present in the premalignant duet like struetures. The epithelium of pretnaligiiant lesions, duet-like struetures. multieystic lesions, and squatiious-cell eareinomas wete positive for the cell-surface and intercellular substances; and tiasenient membranes and stromal fibers were also positive. The results itidicated that throughout tnalignant ttansfortiiation of the ductal segments, pretnalignant epithelia lost Con A-HRP-staining granules and that Con A-binding patterns in induced squatnous-eell eareinomas were similar to those found in squatnous-cell epitheliutn.

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The target cell in the chemical induction of carcinomas in mouse submandibular gland

Cited by 19 publications

References 8 publications

Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland

Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland

Immunohistochemical detection of keratin proteins in salivary gland ducts of mammals.

Histochemical studies on Concanavalin A‐binding in experimental carcinoma of the mouse submandibular gland

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