Abstract. We show that a low energy beta-beam facility can be used to search for sterile neutrinos by measuring the disappearance of electron anti-neutrinos. This channel is particularly sensitive since it allows us to use inverse beta decay as a detection reaction; thus it is free from hadronic uncertainties, provided the neutrino energy is below the pion production threshold. This corresponds to a choice of the Lorentz γ ≃ 30 for the 6 He parent ion. Moreover, a disappearance measurement allows the constraint of sterile neutrino properties independently of any CP violating effects. A moderate detector size of a few 100 tons and ion production rates of ∼ 2 · 10 13 s −1 are sufficient to constrain mixing angles as small as sin 2 2θ = 10 −2 at 99% confidence level.