The telomere attrition rate is not accelerated in women born small for gestational age: A birth cohort study

Melo, Anderson Sanches de; Reis, Rosana Maria dos; Calado, Rodrigo T.; Cavalli, Ricardo de Carvalho; Bettiol, Heloísa; Cardoso, Viviane Cunha; Ferriani, Rui Alberto; Barbieri, Marco Antônio; Vieira, Carolina Sales

doi:10.1016/j.gene.2016.11.030

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…Furthermore, studies have shown an impact of the intrauterine environment, as reflected by abnormal fetal growth, on telomere length in newborns 19,24 . In contrast, other studies have failed to show association between telomere length and birth weight, length or gestational age 25 as well as to phenotype in adults aged from 16–51 years exposed to an adverse fetal environment 21,22,26 . A recent study found no difference in telomere shortening during a five-year period between adult individuals born small for gestational age (SGA) and appropriate for gestational age (AGA) 21 .…”

Section: Discussionmentioning

confidence: 81%

“…In contrast, other studies have failed to show association between telomere length and birth weight, length or gestational age 25 as well as to phenotype in adults aged from 16–51 years exposed to an adverse fetal environment 21,22,26 . A recent study found no difference in telomere shortening during a five-year period between adult individuals born small for gestational age (SGA) and appropriate for gestational age (AGA) 21 . This is further supported by a larger study including 49–51 year-old males and females, where no associations between blood telomere length and birth weight was observed 26 .…”

Section: Discussionmentioning

confidence: 81%

“…Studies have shown that maternal stress and smoking during pregnancy is positively associated with shortened telomeres in the offspring 16,17 and poor fetal growth has been shown to be associated with shorter telomeres in newborns 18,19 as well as in adolescents 20 . However, a recent study found no increased acceleration of telomere shortening in adult women born small for gestational age 21 , and another study found no evidence of telomere abnormalities and oxidative DNA damage in adult offspring of type 1 diabetes mothers as compared to control individual 22 .…”

Section: Introductionmentioning

confidence: 90%

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Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

Grunnet

Pilgaard

Alibegovic

et al. 2019

Sci Rep

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Telomeres are protein-bound regions of repetitive nucleotide sequences (TTAGGG) at the end of human chromosomes, and their length is a marker of cellular aging. Intrauterine growth restriction is associated with shorter blood cell telomeres at birth and individuals with type 2 diabetes have shorter telomeres. Individuals with a low birth weight (LBW) have an increased risk of metabolic disease and type 2 diabetes. Therefore, we aimed to investigate the relationship between birth weight and telomere length and the association between birth weight, telomere length and cardiometabolic phenotype in adulthood. Young, healthy men with LBW (n = 55) and normal birth weight (NBW) (n = 65) were examined including blood pressure, blood samples and body composition. Leukocyte telomere length was determined using a high-throughput qPCR method. The LBW men were more insulin resistant as determined by the HOMA-IR index. There was no difference in telomere length between LBW and NBW subjects. When adjusting for birth weight and cohort effect, significant negative associations between telomere length and fasting glucose (P = 0.003) and HbA1c (P = 0.0008) were found. In conclusion, no significant difference in telomere length was found between LBW and NBW men. The telomere length was negatively associated with glucose concentrations and HbA1c levels within the normal non-diabetic range independent of birth weight.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

Grunnet

Pilgaard

Alibegovic

et al. 2019

Sci Rep

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“…Eight papers studied childhood adiposity (age range 2–17 years), of which 5 estimates were from studies of overweight/obese vs. non-obese children 12 – 15 , 25 , and 3 were studies of body mass index as a continuous measure 16 – 18 . Longitudinal studies assessed neonatal adiposity, and telomere length after a follow-up (range: ~23–69 years) 21 , 36 – 38 : two studied small- versus appropriate-for-gestational age neonates 36 , 37 , and two studied birth weight as a continuous exposure 21 , 38 .…”

Section: Resultsmentioning

confidence: 99%

“…All longitudinal studies included in the meta-analysis measured adiposity only in neonates (i.e. no studies measured adiposity in childhood), with telomere length measured as early as 23.8 (SD 0.7) years 37 and as late as 69 years 21 . Pooled estimates are shown in Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

Early life adiposity and telomere length across the life course: a systematic review and meta-analysis

Guyatt

Rodriguez²,

Gaunt³

et al. 2018

Wellcome Open Res

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Background: The relationship between adiposity at birth and in childhood, and telomere length is yet to be determined. We aimed to systematically review and meta-analyse the results of studies assessing associations between neonatal and later childhood adiposity, and telomere length. Methods: We searched Medline, EMBASE and PubMed for studies reporting associations between adiposity measured in the neonatal period or later childhood/adolescence, and leucocyte telomere length, measured at any age via quantitative polymerase chain reaction, or terminal restriction fragment analysis, either cross-sectionally, or longitudinally. Papers published before April 2017 were included. Results: Out of 230 abstracts assessed, 23 papers (32 estimates) were retained, from which 19 estimates were meta-analysed (15 cross-sectional, four longitudinal). Of the 15 cross-sectional estimates, seven reported on neonates: four used binary exposures of small-for-gestational-age vs. appropriate-for-gestational age (or appropriate- and large-for-gestational age), and three studied birth weight continuously. Eight estimates reported on later childhood or adolescent measures; five estimates were from studies of binary exposures (overweight/obese vs. non-obese children), and three studies used continuous measures of body mass index. All four longitudinal estimates were of neonatal adiposity, with two estimates for small-for-gestational-age vs. appropriate-for-gestational age neonates, and two estimates of birth weight studied continuously, in relation to adult telomere (49-61 years). There was no strong evidence of an association between neonatal or later childhood/adolescent adiposity, and telomere length. However, between study heterogeneity was high, and there were few combinable studies. Conclusions: Our systematic review and meta-analysis found no strong evidence of an association between neonatal or later childhood or adolescent adiposity and telomere length.

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Maternal stress during pregnancy and small for gestational age birthweight are not associated with telomere length at 11 years of age

Slykerman

Joglekar

Hardikar

et al. 2019

Gene

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The telomere attrition rate is not accelerated in women born small for gestational age: A birth cohort study

Cited by 5 publications

References 26 publications

Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

Early life adiposity and telomere length across the life course: a systematic review and meta-analysis

Maternal stress during pregnancy and small for gestational age birthweight are not associated with telomere length at 11 years of age

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The telomere attrition rate is not accelerated in women born small for gestational age: A birth cohort study

Cited by 5 publications

References 26 publications

Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

Early life adiposity and telomere length across the life course: a systematic review and meta-analysis

Maternal stress during pregnancy and small for gestational age birthweight are not associated with telomere length at 11 years of age

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Maternal stress during pregnancy and small for gestational age birthweight are not associated with telomere length at 11 years of age