The temporal relationship between the luteinizing hormone surge and human oocyte maturation

Seibel, Machelle M.; Smith, Deborah Deutsch; Levesque, Linda; Borten, Max; Taymor, Melvin L.

doi:10.1016/0002-9378(82)90763-3

Cited by 77 publications

(29 citation statements)

References 9 publications

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“…The threshold amplitude to define an LH surge is still a matter of debate, but levels more than 10 IU/L are commonly reported (16), although a doubling from basal level could be a more appropriate definition, particularly for patients with high basal LH levels. The duration of LH surge required to reinitiate meiosis seems to be 14-18 hours (23,24), whereas metaphase II oocytes are obtainable in 28 hours after the onset of the LH surge. Therefore, in the presence of a starting spontaneous endogenous LH peak (LH >10 IU/L and P<1.5 ng/mL), the second puncture has to be planned 24 hours later.…”

Section: Discussionmentioning

confidence: 96%

“Empty follicle syndrome” after human error: pregnancy obtained after repeated oocyte retrieval in a gonadotropin-releasing hormone antagonist cycle

Snaifer

Hugues

Poncelet

et al. 2008

Fertility and Sterility

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Section: Discussionmentioning

confidence: 96%

“Empty follicle syndrome” after human error: pregnancy obtained after repeated oocyte retrieval in a gonadotropin-releasing hormone antagonist cycle

Snaifer

Hugues

Poncelet

et al. 2008

Fertility and Sterility

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“…Testart et al (7) demonstrated that the ideal time for oocyte collection in IVF cycles is 34-35 h after the initiation of LH surge. Testart and Frydman showed that the onset of LH rise was found to be a more accurate criterion than the LH peak in determining the time of ovulation (9).…”

Section: Discussionmentioning

confidence: 99%

Clomiphene citrate induced ovulation and intrauterine insemination: effect of timing of human chorionic gonadotropin injection in relation to the spontaneous LH surge on pregnancy rates

Madankumar

Tsang

Lesser

et al. 2005

J Assist Reprod Genet

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Purpose : To determine the optimal time for administration of human chorionic gonadotropin in clomiphene citrate induced intrauterine insemination cycles. Methods : A retrospective analysis of 171 consecutive cycles was performed. An increase in luteinizing hormone level >100% over the mean of the preceding two days was defined as luteinizing hormone surge. Human chorionic gonadotropin was given in preparation for intrauterine insemination based on the follicle size and estradiol level prior to surge in 85 cycles (Group A), with the spontaneous surge in 64 cycles (Group B) and not given in 22 cycles (Group C) due to high luteinizing hormone levels. Results : The overall pregnancy rate per cycle was 18.1% (31/171), 15.2% (Group A), 20.3% (Group B) and 22.7% (Group C), (p > 0.50). Conclusion : Although there may be physiological reasons to propose that timing the human chorionic gonadotropin to the luteinizing hormone surge will improve the success rate, they were not demonstrated.

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“…Oocyte meiotic maturation is induced by hCG. Usually the resumption of meiosis and achievement of second metaphase take place within 18 and 28-38 h, respectively, following the LH surge or in vitro culture [14,15]. Although the women are exposed to hCG for 36 h, a length of time sufficient to induce the ovulatory processes [16], sometimes the aspirated oocytes fail to resume meiosis in vivo and even after a subsequent 20-h incubation in vitro.…”

Section: Introductionmentioning

confidence: 99%

Failure of Meiotic Competence in Human Oocytes1

Bar‐Ami

Zlotkin

Brandes

et al. 1994

Biology of Reproduction

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The administration of hCG to women undergoing in vitro fertilization and embryo transfer (IVF/ET) results in the meiotic maturation of cumulus-oocyte complexes (COC). Sometimes oocytes being aspirated for IVF/ET fail to resume meiosis in vivo and even after a subsequent 20-h incubation in vitro and are thus defined as meiotic competence failure (MCF) oocytes. The relationship between the proportion of MCF oocytes and other IVF/ET outcomes was studied over 3 years in 703 tested cycles of 487 women. Women yielding one or more MCF oocytes in at least one menstrual cycle represented 8.6% of this population and were defined as MCF women. Cumulus state in the MCF oocyte population was characterized as mature in 57.4 +/- 6.7%, intermediate in 13.9 +/- 4.0%, immature in 24.1 +/- 8.7%, and atretic in 4.6 +/- 2.7%. These values differed significantly, by 0.6-, 2.9-, 7.1-, and 4.6-fold, respectively, as compared to the corresponding COC aspirated from women yielding only meiotically competent (MC) oocytes. In a menstrual cycle yielding both MC and MCF oocytes, the IVF/ET variables were evaluated in the MC oocytes. Thus, in such cases the incidence of fertilization or cleavage and the number of blastomeres per embryo were significantly reduced concomitant with the increase in percentage of MCF oocytes. When the percentage of MCF oocytes was 25% or more, no pregnancy was achieved. Various follicular parameters and serum 17 beta-estradiol (E2) and progesterone (P4) levels were compared in MC and MCF women over the four days preceding day of aspiration.(ABSTRACT TRUNCATED AT 250 WORDS)

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The temporal relationship between the luteinizing hormone surge and human oocyte maturation

Cited by 77 publications

References 9 publications

“Empty follicle syndrome” after human error: pregnancy obtained after repeated oocyte retrieval in a gonadotropin-releasing hormone antagonist cycle

“Empty follicle syndrome” after human error: pregnancy obtained after repeated oocyte retrieval in a gonadotropin-releasing hormone antagonist cycle

Clomiphene citrate induced ovulation and intrauterine insemination: effect of timing of human chorionic gonadotropin injection in relation to the spontaneous LH surge on pregnancy rates

Failure of Meiotic Competence in Human Oocytes1

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