The TH1 Lymphokine Interferon-γ is a Potent Upregulator of Dendritic Cells with Phagocytic Capacity in GM-CSF Supplemented Bone Marrow Cultures

Scheicher, Christoph; Corban, Heike; Hof, Vera; Robbers, Michael; Reske, Konrad

doi:10.1007/978-1-4757-9966-8_37

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Ozawa et al reported that IFN-␥ reduced Langerhans cell antigen-presenting capacity [36]. In other studies, IFN-␥ up-regulated the phagocytic activity of murine bone-marrowderived DC, increased CD86 expression in human Langerhans cells, and enhanced antigen presentation [37][38][39][40].…”

Section: Discussionmentioning

confidence: 97%

Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-γ and CD40 ligation

Nardelli

Morahan

Bong

et al. 1999

Journal of Leukocyte Biology

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Section: Discussionmentioning

confidence: 97%

Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-γ and CD40 ligation

Nardelli

Morahan

Bong

et al. 1999

Journal of Leukocyte Biology

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“…The modulating influence of IFN-␥ alone on monocyte-derived DC has been discussed controversially: although some studies demonstrate an enhancing effect of IFN-␥ on DC maturation and function (35,36), others describe a down-regulation of immunostimulatory capacity in the human (37) and in the murine (38) system. In our study, DC pretreated with IFN-␥ caused only a marginal enhancement of lymphocyte proliferation and production of IFN-␥ (see Figs.…”

Section: Discussionmentioning

confidence: 99%

The Toll-Like Receptor-2/6 Agonist Macrophage-Activating Lipopeptide-2 Cooperates with IFN-γ to Reverse the Th2 Skew in an In Vitro Allergy Model

Weigt

Mühlradt²,

Larbig

et al. 2004

The Journal of Immunology

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Dendritic cells (DC) are the most potent APCs with the capacity to induce, modulate, or shut down immune function. These features make them potentially useful for treating diseases associated with misled immunologic responses. Therefore, it was the aim of this study to reverse the allergen-dependent Th2 reaction responsible for allergic symptoms by modulating DC function. This issue was addressed in an in vitro test system consisting of human monocyte-derived allergen-pulsed DC from allergics cocultured with autologous lymphocytes. A Th2 reaction judged by the amplification of IL-4 and the down-regulation of IFN-γ was induced by pulsing DC with the relevant allergen. To modulate this reaction, the Toll-like receptor 2/6 engaging mycoplasmal lipopetide macrophage-activating lipopeptide 2 kDa was combined with IFN-γ to stimulate allergen-pulsed DC. Such treatment resulted in a 500-fold increase in IFN-γ production in the supernatant of cocultured autologous lymphocytes, while the Th2 marker IL-4 was not affected. This phenomenon was associated with an increase in proliferation and the number of IFN-γ-producing lymphocytes. Phenotype and function of thus treated DC remained stable. These data indicate that a former allergen-dependent Th2 reaction can be reversed toward a Th1-type response by an appropriate treatment of DC.

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The TH1 Lymphokine Interferon-γ is a Potent Upregulator of Dendritic Cells with Phagocytic Capacity in GM-CSF Supplemented Bone Marrow Cultures

Cited by 2 publications

References 13 publications

Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-γ and CD40 ligation

Dendritic cells and MPIF-1: chemotactic activity and inhibition of endogenous chemokine production by IFN-γ and CD40 ligation

The Toll-Like Receptor-2/6 Agonist Macrophage-Activating Lipopeptide-2 Cooperates with IFN-γ to Reverse the Th2 Skew in an In Vitro Allergy Model

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