2013
DOI: 10.1016/j.jep.2012.10.059
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The Th1/Th2/Th17/Treg paradigm induced by stachydrine hydrochloride reduces uterine bleeding in RU486-induced abortion mice

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Cited by 46 publications
(23 citation statements)
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“…Homostachydrine has been reported in citrus genus plants [48], but with no biological activity defined. Stachydrine was significantly elevated in plasma of EAE, which was recently shown to activate Th17/Th1 by reducing Th2/Treg in RU486 induced mouse model [49]. This observation agrees with the identified higher levels of stachydrine, increased inflammation and severity in SJL mice with EAE (Figure 1).…”
Section: Resultssupporting
confidence: 89%
“…Homostachydrine has been reported in citrus genus plants [48], but with no biological activity defined. Stachydrine was significantly elevated in plasma of EAE, which was recently shown to activate Th17/Th1 by reducing Th2/Treg in RU486 induced mouse model [49]. This observation agrees with the identified higher levels of stachydrine, increased inflammation and severity in SJL mice with EAE (Figure 1).…”
Section: Resultssupporting
confidence: 89%
“…53 These subsets include the T helper cell type 1 (Th1), T helper cell type 2 (Th2), Th17 cells, and Treg cells. 54,55 Th1 cells are characterized by the production of pro-inflammatory cytokines such as interleukin-2 (IL-2), interferonγ (IFNγ), and tumor necrosis factor α (TNFα). These molecules are involved in cellular immunity and host defense against intracellular pathogens.…”
Section: Adap Tive Immune Sys Tem and Preg Nan C Ymentioning
confidence: 99%
“…The stability of T-reg and TH17 phenotypes may not be strong (Sakaguchi, et al 2013), as conversion can occur in the context of hormonal disregulation (Li, et al 2013) severe infection (Rowe, et al 2012a, Zhang, et al 2012) and TLR signaling (Nyirenda, et al 2011). Understanding the various mechanisms by which thymic or peripheral T regs exert their effects on T cells is ongoing, and can include suppression of cytokine production and proliferation (Thornton and Shevach 1998) direct killing (Abdulahad, et al 2011) and modulation of function(Collison, et al 2009) (Zelinskyy, et al 2013).…”
Section: Introductionmentioning
confidence: 99%