The therapeutic concept of “patient management” in atopic eczema

Ring, Johannes; Brockow, Knut; Abeck, Dietrich

doi:10.1111/j.1398-9995.1996.tb04595.x

Cited by 64 publications

(30 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the therapy of superinfected AE topical disinfectants or antibiotics are often added to glucocorticosteroids [12]. In the last decades its value has been discussed controversially.…”

Section: Discussionmentioning

confidence: 99%

Effect of Gentian Violet, Corticosteroid and Tar Preparations in Staphylococcus-aureus-Colonized Atopic Eczema

et al. 1999

View full text Add to dashboard Cite

Background: In atopic eczema (AE), skin colonization with Staphylococcus aureus plays a possible role in the pathophysiology of the disease. Methods: Thirty-eight patients with AE were screened for their cutaneous colonization with S. aureus. The antibacterial and clinical efficacy of topical therapy with the antiseptic dye gentian violet, a potent glucocorticosteroid or a tar solution (liquor carbonis detergens) was evaluated in vivo in 21 patients with a density of >10⁴ CFU/cm² and in vitro. Skin sites were treated twice daily for 4 days with the active drug or a corresponding control. Quantification of S. aureus was done daily during therapy as well as 3 days thereafter. The severity of the lesions was rated by a regional SCORAD. Results: In gentian-violet-treated skin, bacterial density decreased significantly in lesional (p < 0.001) and unaffected skin (p < 0.001). Bacterial densities did not decrease during therapy with glucocorticosteroid or liquor carbonis detergens but dropped afterwards. All therapeutics reduced the severity score, reduction being greatest for the glucocorticosteroid and lowest for liquor carbonis detergens. In vitro, a high antibactericidal efficacy was demonstrated only for gentian violet. Conclusions: Antibacterial therapy with gentian violet not only reduces S. aureus dramatically, but also reduces the severity of the eczema. Reduction of S. aureus after therapy with glucocorticosteroids and LCD seems to be secondary to improvement of the skin condition.

show abstract

“…In the therapy of superinfected AE topical disinfectants or antibiotics are often added to glucocorticosteroids [12]. In the last decades its value has been discussed controversially.…”

Section: Discussionmentioning

confidence: 99%

Effect of Gentian Violet, Corticosteroid and Tar Preparations in Staphylococcus-aureus-Colonized Atopic Eczema

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Although there is a controversial discussion about topical glucocorticoid and antibiotic combination, antibiotic as well as antiseptic substances of good antistaphylococcal activity have been well established and are successfully used for the treatment of AE. By reduction of S. aureus density they are able to contribute to the anti-inflammatory effect of topical corticosteroids and emollients [10, 11, 12, 13]. Silver products have been under investigation during recent years with special regard to wound-healing processes.…”

Section: Introductionmentioning

confidence: 99%

Silver-Coated Textiles Reduce Staphylococcus aureus Colonization in Patients with Atopic Eczema

Gauger¹,

Mempel²,

Schekatz³

et al. 2003

Dermatology

117

View full text Add to dashboard Cite

Background: In atopic eczema (AE), skin colonization with Staphylococcus aureus is known to play a major triggering and possibly pathophysiological role. Methods: In this open-labeled controlled side-to-side comparative trial, affected sites (flexures of both elbows) in 15 patients diagnosed as having generalized or localized AE were evaluated regarding S. aureus colonization and clinical severity of AE over a 2-week period. Flexures of the elbows were covered with silver-coated textiles on one arm and cotton on the other for 7 days followed by a 7-day control period. Results: A highly significant decrease in S. aureus colonization could be seen on the site covered by the silver-coated textile already 2 days after initiation lasting until the end of the treatment. Seven days after cessation, S. aureus density remained significantly lower compared to baseline. In addition, significantly lower numbers of S. aureus were observed on the silver-coated textile site in comparison to cotton at the end of treatment as well as at the time point of control. Clinical improvement correlated with the reduction of S. aureus colonization. Conclusion: A superior improvement achieved by silver-coated compared to cotton textiles paralleled a potent anti-S.-aureus effect.

show abstract

“…In addition, the SAS can improve communication between the parents/patients and the physician. This improvement in communication can increase self-confidence and motivation, with a positive effect on the therapy compliance of patients [15,16,17,18]. The ETFAD created an SAS based on the SCORAD index, called the Patient-Oriented SCORAD (PO-SCORAD).…”

Section: Introductionmentioning

confidence: 99%

Correlation between Objective SCORAD and Three-Item Severity Score Used by Physicians and Objective PO-SCORAD Used by Parents/Patients in Children with Atopic Dermatitis

Oosterhout¹,

Janmohamed

Spierings³

et al. 2015

Dermatology

View full text Add to dashboard Cite

Background: A self-assessment rating scale (SAS) is a good tool to assess the fluctuating disease severity and quality of life (QoL) in children with atopic dermatitis (AD). The European Task Force on Atopic Dermatitis created an SAS based on the Scoring Atopic Dermatitis (SCORAD) index, called the Patient-Oriented SCORAD (PO-SCORAD). Objective: The aim of our study was to measure the correlation between alternative systems such as the Objective SCORAD, the Three-Item Severity (TIS) score and the Objective PO-SCORAD. We also investigated the correlations between the objective severity assessments and QoL. Methods: In a specialized outpatient clinic, an observational prospective study was performed with children ≤16 years with AD. Results: Seventy-five children were included. A good and significant correlation was shown between Objective SCORAD and Objective PO-SCORAD: Spearman's ρ correlation (r_s) = 0.63 (p < 0.001). The correlation with QoL was moderate, but still significant (r_s = 0.41-0.61, p < 0.001). Conclusion: The Objective PO-SCORAD can be used for the evaluation of fluctuating AD and correlates significantly with the Objective SCORAD and the less time-consuming TIS score.

show abstract

The therapeutic concept of “patient management” in atopic eczema

Cited by 64 publications

References 103 publications

Effect of Gentian Violet, Corticosteroid and Tar Preparations in <i>Staphylococcus</i>-aureus-Colonized Atopic Eczema

Effect of Gentian Violet, Corticosteroid and Tar Preparations in <i>Staphylococcus</i>-aureus-Colonized Atopic Eczema

Silver-Coated Textiles Reduce <i>Staphylococcus aureus </i>Colonization in Patients with Atopic Eczema

Correlation between Objective SCORAD and Three-Item Severity Score Used by Physicians and Objective PO-SCORAD Used by Parents/Patients in Children with Atopic Dermatitis

Contact Info

Product

Resources

About