The therapeutic effect of Cinnamomum cassia essential oil against hepatotoxicity induced by co-exposure to lead and manganese in developing Wistar rats

Adli, Djallal Eddine Houari; Brahmi, Mostapha; Khaled, K.F.; Arabi, Wafaa; Bouzouira, Bakhta; Talatizi, Mustapha; Slimani, Miloud

doi:10.22270/jddt.v10i5.4361

Cited by 5 publications

(8 citation statements)

References 24 publications

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“…In addition, it is possible that Trévo TM chelate PbA, thus preventing it from binding to a functional molecule such as albumin. Our result also supported the oxidative stress-induced mechanism of PbA as reported by other researchers [2][3][4]16,17]. PbA exposure caused a mild increase in MDA level as well as a significant decrease in GSH concentration, CAT, SOD, and GST activities in liver tissue.…”

Section: Discussionsupporting

confidence: 92%

“…The toxicity of lead has been reported to cause liver injury, osteoporosis, neurological disorders, and cardiovascular diseases [3]. The accepted mechanism of lead toxicity is oxidative stress [2][3][4]16,17]. This is often achieved by generating free radicals and depleting the antioxidant systems.…”

Section: Introductionmentioning

confidence: 99%

“…Since the major mechanism of lead toxicity is oxidative stress, natural products rich in antioxidants can be a good antidote against lead poison and can be used along with common lead chelators. Several compounds from natural products with confirmed antioxidant activities have been used as a hepatoprotective agent against lead position [2,3,7,16,17].…”

Section: Introductionmentioning

confidence: 99%

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Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement

Ilesanmi

Adeogun

Odewale

et al. 2022

Environ Anal Health Toxicol

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Lead exposure has been linked to health challenges involving multiple organ failure. More than fifty percent of lead present in the human body is accumulated in the liver causing hepatic injury. A major mechanism of lead toxicity is oxidative stress. TrévoTM is a nutritional supplement with numerous bioactive natural products with detoxifying and antioxidant properties. This study was designed to investigate the hepatoprotective effects of TrévoTM dietary supplements against lead-hepatotoxicity in male Wistar rats. Thirty-five healthy animals were divided into five groups of seven each as follows: Group I=control; II=15 mg/kg of lead acetate (PbA); III= 2 mL/kg of TrévoTM + PbA; IV= 5 mL/kg of TrévoTM + PbA;V=5 mL/kg of TrévoTM . Animals were orally treated with TrévoTM for two days before co-administration with PbA intraperitoneally for 12 consecutive days. Animals were sacrificed 24 h after the last administration and blood were collected via cardiac puncture and processed for hematological parameters and assessment of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and albumin (ALB). The liver was excised and processed for markers of oxidative stress and histopathological examination. Intraperitoneal administration of 15 mg/kg of PbA caused a significant increase in serum concentration of AST, ALT, while the concentration of ALB was significantly decreased (P<0.001). PbA caused a significant reduction in packed cell volume, hemoglobin while the total white blood cell count, neutrophils, lymphocytes, monocytes, eosinophils, and basophils were increased. Oxidative stress was significantly pronounced in the liver of rats exposed to PbA as observed in the high concentration of malonedialdehyde, decreased concentration of glutathione, the activity of catalase, superoxide dismutase, and glutathione-S-transferase. Pretreatment with TrévoTM was able to significantly prevent the anemic, oxidative damage, and hepatic injury initiated by PbA. Histological examination also corroborated the biochemical results. In conclusion, the study reveals that TrévoTM is effective in attenuating PbA-induced hepatotoxicity in male Wistar rats.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement

Ilesanmi

Adeogun

Odewale

et al. 2022

Environ Anal Health Toxicol

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“…However, Mn 2+ has more pronounced effects than those of Mn 3+ . On this line, few other studies also reported oxidative stress and an altered antioxidant level following exposure to Mn in different experimental settings (Adli et al, 2020; Chandel & Jain, 2016; Ismail, 2019; Markiewicz‐Górka et al, 2015; Oladipo et al, 2016; Tong et al, 2020). Along with oxidative stress, few studies have also highlighted the Mn‐mediated increases in the levels of few inflammatory cytokines such as tumor necrosis factor‐alpha (TNF‐α), interleukin‐1 beta (IL‐1β), and interleukin‐6 (IL‐6), and neutrophil marker (myeloperoxidase) (Fan et al, 2020; Owumi & Dim, 2019).…”

Section: Experimental Evidence Of Mn‐induced Organ Toxicitymentioning

confidence: 89%

The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions

Gandhi¹,

Rudrashetti

Rajasekaran³

2021

J of Applied Toxicology

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Manganese (Mn) is an essential trace element for humans, but long‐term environmental or occupational exposures can lead to numerous health problems. Although many studies have identified an association between Mn exposures and neurological abnormalities, emerging data suggest that occupationally and environmentally relevant levels of Mn may also be linked to multiple organ dysfunction in the general population. In this regard, many experimental and clinical studies provide support for a causal link between Mn exposure and structural and functional changes that are responsible for organ dysfunction in major organs like lung, liver, and kidney. The underlying mechanisms suggested to Mn toxicity include altered activities of the components of intracellular signaling cascades, oxidative stress, apoptosis, affected cell cycle regulation, autophagy, angiogenesis, and an inflammatory response. We further discussed the sources and possible mechanisms of Mn absorption and distribution in different organs. Finally, treatment strategies available for treating Mn toxicity as well as directions for future studies were discussed.

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“…Succimer, penicillamine, and BAL cause gastrointestinal problems, whereas http://eaht.org EDTA causes calcium shortage and consequent kidney injury [13]. Furthermore, they are unable to restore related adverse effects, such as toxicant redistribution, metal loss, and hepatic or renal dysfunction [14,15]. Natural organic products are increasingly being used to mitigate the damaging effects of heavy metals and other hazardous pollutants.…”

Section: Introductionmentioning

confidence: 99%

Antagonistic effectiveness of Anacardium occidentale leaf extract on lead-acetate exposure-induced hepatorenal toxicity in rats

Aminu,

Umar,

Makena

et al. 2023

Environ Anal Health Toxicol

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Lead (Pb) poisoning is an environmental substance that accumulates in the hepato-renal tissue, which is hazardous to health, while Anacardium occidentale L. is a tropical herb used to treat oxidative stress and inflammatory diseases. The aim of this study was to investigate the antagonistic effect of Anacardium occidentale leaf extract on lead acetate exposure-induced hepatorenal toxicity in rats. Thirty-six adult Wistar rats were split into six equal groups (n = 6). Group I served as a control, and groups II and III were administered lead acetate (50 mg/kg) and Anacardium occidentale leaf extract (400 mg/kg), respectively, while rats in groups IV–VI were administered Anacardium occidentale (L) extract (200 mg/kg and 400 mg/kg) and 10 mg/kg of Succimer, respectively, and were then administered lead acetate (50 mg/kg). When compared to the group I, rats administered lead acetate showed an increase in hepatic enzymes, urea, creatinine, MDA, TNF-α, and IL-1β (p < 0.001) levels and decreased levels of SOD, CAT, and GSH, whereas Anacardium occidentale prevented the increase in hepatorenal function parameters, oxidative stress, and inflammatory markers (TNF-α and IL-1β) induced by lead acetate. Rats administered only lead acetate had a marked increase in hepatic Pb concentration, severe hepatic steatosis, and renal glomerulus degeneration. However, treatment with Anacardium occidentale extract and succimer decreases the Pb concentration, oxidative stress, and inflammation, and also reduces histological liver steatosis and glomerular cytoarchitecture deterioration in the kidney. The results of this study revealed that Anacardium occidentale extract protects against lead acetate-induced liver and kidney toxicity by decreasing oxidative stress and inflammation.

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The therapeutic effect of Cinnamomum cassia essential oil against hepatotoxicity induced by co-exposure to lead and manganese in developing Wistar rats

Cited by 5 publications

References 24 publications

Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement

Lead exposure-induced changes in hematology and biomarkers of hepatic injury: protective role of TrévoTM supplement

The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions

Antagonistic effectiveness of Anacardium occidentale leaf extract on lead-acetate exposure-induced hepatorenal toxicity in rats

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