The Therapeutic Effect of Folic Acid in Tropical Sprue

Spies, Tom D.; Suárez, Ramón M.; Hernandez-Morales, F

doi:10.1126/science.104.2691.75

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…The tolerable upper intake level (UL) (1000 μg/day)of folic acid was established as one-fifth of the lowest observed adverse effect level (5000 μg/day) associated with a potential adverse outcome [ 32 ]. Even at dosages of 15,000–100,000 μg of folic acid daily, limited evidence was found of direct toxicity from folic acid [ 33 – 38 ]. However recently the possibility that folic acid intake might lead to changes in epigenetic patterns and thus the plausible hypotheses of how folic acid might affect certain diseases has led to concerns about higher folic acid intake and food fortification programs.…”

Section: Discussionmentioning

confidence: 99%

The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

et al. 2016

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BackgroundMigraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the occurrence of migraine in response to vitamin supplementation with a lower dose of folic acid.MethodsThis was a 6 month randomised, double blinded placebo controlled trial of daily vitamin supplementation containing 1 mg of folic acid, 25 mg of Vitamin B6 and Vitamin B12, on reduction of homocysteine and the occurrence of migraine in 300 female patients diagnosed with migraine with aura.ResultsVitamin supplementation with 1 mg of folic acid, did not significantly decrease homocysteine levels (P = 0.2). The treatment group did not show a significant decrease in the percentage of participants with high migraine disability, severity or frequency at the end of the 6 month intervention (P > 0.1).Conclusion1 mg of folic acid in combination with vitamin B6 and B12 is less effective in reducing migraine associated symptoms compared to the previously tested dosage of 2 mg folic acid in combination with 25 mg of vitamin B6 and 400 μg of vitamin B12.

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Section: Discussionmentioning

confidence: 99%

The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

et al. 2016

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“…Even at dosages of 15,000–100,000 μg of folic acid daily, the IOM found limited evidence of direct toxicity from folic acid [53,54,55,56,57,58]. Recent studies have shed light on the means by which the intake would exceed the UL for most individuals.…”

Section: Effect Of Mandatory Fortification Of Food With Folic Acidmentioning

confidence: 99%

“…The tolerable upper intake level (UL) (1000 μg/day) was established by the IOM in 1998 as one-fifth of the lowest observed adverse effect level (5000 μg/day) associated with a potential adverse outcome in early case reports (the masking of vitamin B12 deficiency anemia) [ 15 ]. Even at dosages of 15,000–100,000 μg of folic acid daily, the IOM found limited evidence of direct toxicity from folic acid [ 53 , 54 , 55 , 56 , 57 , 58 ]. Recent studies have shed light on the means by which the intake would exceed the UL for most individuals.…”

Section: Effect Of Mandatory Fortification Of Food With Folic Acidmentioning

confidence: 99%

Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

2011

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Periconceptional intake of folic acid is known to reduce a woman’s risk of having an infant affected by a neural tube birth defect (NTD). National programs to mandate fortification of food with folic acid have reduced the prevalence of NTDs worldwide. Uncertainty surrounding possible unintended consequences has led to concerns about higher folic acid intake and food fortification programs. This uncertainty emphasizes the need to continually monitor fortification programs for accurate measures of their effect and the ability to address concerns as they arise. This review highlights the history, effect, concerns, and future directions of folic acid food fortification programs.

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“…Sleep disturbances, gastrointestinal effects, and mental changes have only been observed in one uncontrolled, nonblinded trial in which oral doses of folate of 15,000 μg/day were taken for 1 month [82]. "However, " the Institute of Medicine report [27] continues, "studies using comparable or higher dosages, longer durations, or both, failed to confirm these findings" [83][84][85][86][87]. The Institute of Medicine concluded that there was no evidence of direct toxicity of folic acid and no evidence of adverse reproductive effects from folic acid [27].…”

Section: Potential Adverse Effects Of Folic Acidmentioning

confidence: 99%

Fortification of Flour with Folic Acid

Berry¹,

Bailey²,

Mulinare³

et al. 2010

Food Nutr Bull

161

115

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NTDs remain an important cause of perinatal mortality and infantile paralysis worldwide. Mandatory fortification of flour with folic acid has proved to be one of the most successful public health interventions in reducing the prevalence of NTD-affected pregnancies. Most developing countries have few, if any, common sources of folic acid, unlike many developed countries, which have folic acid available from ready-to-eat cereals and supplements. Expanding the number of developed and developing countries with folic acid flour fortification has tremendous potential to safely eliminate most folic acid-preventable NTDs.

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The Therapeutic Effect of Folic Acid in Tropical Sprue

Cited by 7 publications

References 3 publications

The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

Fortification of Flour with Folic Acid

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