The therapeutic efficacy of α-pinene in an experimental mouse model of allergic rhinitis

Nam, Sun‐Young; Chung, Cha-Kwon; Seo, Jung Hun; Rah, So-Young; Kim, Hyung-Min; Jeong, Hyun‐Ja

doi:10.1016/j.intimp.2014.09.010

Cited by 68 publications

(52 citation statements)

References 35 publications

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“…Interestingly, the key to the anti-inflammatory effect of this monoterpene may be related to downregulated ERK and JNK phosphorylation (D.-S. and inhibited NF-κB activity (D.-S. Nam et al, 2014). Our review corroborates the evidence that α-pinene may be a promising anti-inflammatory agent and suggests that it may be useful in the clinical management of inflammatory illness.…”

Section: Moreover Myrtenol a Bioactive Compound Of Many Medicinal Psupporting

confidence: 79%

“…In addition, other articles support the pharmacological evidence which shows that the anti-inflammatory effect are related to TNF-α, IL-1β, and IL-6 inhibition during acute pancreatitis (Bae et al, 2012;Nam et al, 2014). A significant reduction in the levels of inflammatory cytokine such as TNF-α and IL-6 were induced by α-pinene in an ovalbumin-sensitized allergic rhinitis animal model, however, no change was observed in IL-1β levels in the same model (Nam et al, 2014).…”

Section: Moreover Myrtenol a Bioactive Compound Of Many Medicinal Pmentioning

confidence: 74%

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Monoterpenes modulating cytokines - A review

Quintans

Saravanan

Heimfarth

et al. 2019

Food and Chemical Toxicology

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Inflammatory response can be driven by cytokine production and is a pivotal target in the management of inflammatory diseases. Monoterpenes have shown that promising profile as agents which reduce the inflammatory process and also modulate the key chemical mediators of inflammation, such as pro and anti-inflammatory cytokines. The main interest focused on monoterpenes were to develop the analgesic and anti-inflammatory drugs. In this review, we summarized current knowledge on monoterpenes that produce anti-inflammatory effects by modulating the release of cytokines, as well as suggesting that which monoterpenoid molecules may be most effective in the treatment of inflammatory disease. Several different inflammatory markers were evaluated as a target of monoterpenes. The proinflammatory and antiinflammatory cytokines were found TNF-α, IL-1β, IL-2, IL-5, IL-4, IL-6, IL-8, IL-10, IL-12 IL-13, IL-17A, IFNγ, TGF-β1 and IFN-γ. Our review found evidence that NF-κB and MAPK signaling are important pathways for the anti-inflammatory action of monoterpenes. We found 24 monoterpenes that modulate the production of cytokines, which appears to be the major pharmacological mechanism these compounds possess in relation to the attenuation of inflammatory response. Despite the compelling evidence supporting the anti-inflammatory effect of monoterpenes, further studies are necessary to fully explore their potential as anti-inflammatory compounds.

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Section: Moreover Myrtenol a Bioactive Compound Of Many Medicinal Psupporting

confidence: 79%

Section: Moreover Myrtenol a Bioactive Compound Of Many Medicinal Pmentioning

confidence: 74%

Monoterpenes modulating cytokines - A review

Quintans

Saravanan

Heimfarth

et al. 2019

Food and Chemical Toxicology

View full text Add to dashboard Cite

show abstract

“…In ovalbumin-sensitized mouse model of allergic rhinitis, pretreatment with α-pinene decreased clinical symptoms and levels of immunoglobulin E and IL-4 (25). In human chondrocytes, α-pinene inhibited IL-1β-induced inflammation pathway by suppressing NF-κB, c-Jun N-terminal kinase (JNK) activation, and expression of iNOS and matrix metalloproteinases (MMP)-1 and -13, suggesting its role as an anti-osteoarthritic agent (19).…”

Section: Terpenes With Anti-inflammatory Functionmentioning

confidence: 99%

Terpenes from Forests and Human Health

et al. 2017

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Forest bathing has beneficial effects on human health via showering of forest aerosols as well as physical relaxation. Terpenes that consist of multiple isoprene units are the largest class of organic compounds produced by various plants, and one of the major components of forest aerosols. Traditionally, terpene-containing plant oil has been used to treat various diseases without knowing the exact functions or the mechanisms of action of the individual bioactive compounds. This review categorizes various terpenes easily obtained from forests according to their anti-inflammatory, anti-tumorigenic, or neuroprotective activities. Moreover, potential action mechanisms of the individual terpenes and their effects on such processes, which are described in various in vivo and in vitro systems, are discussed. In conclusion, the studies that show the biological effectiveness of terpenes support the benefits of forest bathing and propose a potential use of terpenes as chemotherapeutic agents for treating various human diseases.

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“…In ovalbumin-sensitized mouse model of allergic rhinitis, pretreatment with α-pinene decreased clinical symptoms and levels of immunoglobulin E and IL-4 (25). In human chondrocytes, α-pinene inhibited IL-1β-induced inflammation pathway by suppressing NF-κB, cJun N-terminal kinase (JNK) activation, and expression of iNOS and matrix metalloproteinases (MMP)-1 and -13, suggesting its role as an anti-osteoarthritic agent (19).…”

Section: Terpenes With Anti-inflammatory Functionmentioning

confidence: 99%