The therapeutic potential of antimicrobial peptides from frog skin

Structural diversity and species distribution of host-defense peptides in frog skin secretions

“…Skin secretions from many species of Anura (frogs and toads) contain a wide range of compounds with biological activity, often in very high concentrations, that have excited interest because of their potential for drug development [1,2]. Among these substances are peptides with broad-spectrum antibacterial and antifungal activities and the ability to permeabilize mammalian cells.…”

Host defense peptides in skin secretions of Odorrana tiannanensis: Proof for other survival strategy of the frog than merely anti-microbial

“…Besides, there are usually more than one anti-microbial peptide families in a single amphibian species. Most of the AMPs, 10e50 residues in length, have a common highly conserved N-terminal preproregion, followed by a markedly different C-terminal domain that corresponds to mature AMPs [6,7,9]. Functionally, different amphibian antimicrobial peptides have different anti-microbial spectrum.…”

Structure-Activity Relationships of Peptide Antibiotics with Improved Bacterial Cell Selectivity of Pseudin

“…Pseudins (1-4), four structurally related peptides with antimicrobial activity were isolated from an extract of the skin of the paradoxical frog Pseudis paradoxa (Pseudidae). 5 We have determined the tertiary structure of Pseudin-2 (GLNALKKVFQGIHEAIKLINNHVQ) and it revealed that pseudin has a linear α-helix from Leu 2 to Glu24. 6 Since pseudin has high cytotoxicity against mammalian cells, we tried to design more potent peptides.…”