The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants

Abstract

The skin serves as the body’s first line of defense, guarding against mechanical, chemical, and thermal damage to the interior organs. It includes a highly developed immune response that serves as a barrier against pathogenic infections. Wound healing is a dynamic process underpinned by numerous cellular activities, including homeostasis, inflammation, proliferation, and remodeling, that require proper harmonious integration to effectively repair the damaged tissue. Following cutaneous damage, microorganisms can quickly enter the tissues beneath the skin, which can result in chronic wounds and fatal infections. Natural phytomedicines that possess considerable pharmacological properties have been widely and effectively employed forwound treatment and infection prevention. Since ancient times, phytotherapy has been able to efficiently treat cutaneous wounds, reduce the onset of infections, and minimize the usage of antibiotics that cause critical antibiotic resistance. There are a remarkable number of wound-healing botanicals that have been widely used in the Northern Hemisphere, including Achiella millefolium, Aloe vera, Althaea officinalis, Calendula officinalis, Matricaria chamomilla, Curcuma longa, Eucalyptus, Jojoba, plantain, pine, green tea, pomegranate, and Inula. This review addresses the most often used medicinal plants from the Northern Hemisphere that facilitate the treatment of wounds, and also suggests viable natural alternatives that can be used in the field of wound care.

Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats

“…The use of medicinal plants in wound healing has been traditionally practised in indigenous communities [29]. However, the validation of the wound healing potential of most medicinal plants has not been performed.…”

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

“…[1] These plants were widely employed in various fields such as traditional medicine, agriculture, and human treatment due to the bioactivity of their therapeutic components, resulting in a taxonomic diversity of life. [2] Over the years, many common natural products derived from different parts of these plants such as barks, leaves, flowers, roots, fruits, and seeds have been shown to contain various bioactive components with inhibitory properties. [3] Plant development stages are also influenced by management and human diseases, which may involve the selection or reproduction of plants to preserve their active components.…”

“…Medicinal plants have a long history of usage in traditional medicine since antiquity [1] . These plants were widely employed in various fields such as traditional medicine, agriculture, and human treatment due to the bioactivity of their therapeutic components, resulting in a taxonomic diversity of life [2] . Over the years, many common natural products derived from different parts of these plants such as barks, leaves, flowers, roots, fruits, and seeds have been shown to contain various bioactive components with inhibitory properties [3] .…”

Extracts of Brocchia cinerea (Delile) Vis Exhibit In Vivo Wound Healing, Anti-Inflammatory and Analgesic Activities, and Other In Vitro Therapeutic Effects

“…Wound healing requires a complex, orderly and dynamic process that proceeds through the following stages: coagulation, inflammation, proliferation and remodeling [ 6 ]. For a patient with burns, microorganisms can penetrate into the tissues under the skin, developing chronic and systemic complications [ 7 , 8 ]. Excessive reactive oxygen species also have a negative role on the healing process [ 9 ].…”