The threat of carbapenem-resistant Enterobacteriaceae in Lebanon: An update on the regional and local epidemiology

El-Herte, Rima I.; Kanj, Souha S.; Matar, Ghassan M.; Araj, George F.

doi:10.1016/j.jiph.2012.02.003

Cited by 41 publications

(46 citation statements)

References 67 publications

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“…The NDM-1 gene raised global concern since its first recognition in Pakistan [16] and spread to many other countries via medical tourists [13,16,17,18]. The genes involved in carbapenem resistance among Enterobacteriaceae vary greatly among different countries.…”

Section: Discussionmentioning

confidence: 99%

Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon

El-Herte

Araj

Matar

et al. 2012

J Infect Dev Ctries

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Carbapenem resistance has been encountered globally with poor outcome of infected patients. NDM-1 (New Delhi metallo-beta-lactamase) gene containing organisms have emerged and are now spreading in all continents. This is the first report of Iraqi patients referred to Lebanon from whom carbapenem resistant Enterobacteriaceae were recovered. The genes involved in carbapenem resistance were bla-OXA-48 and the novel NDM-1. This report highlights the alarming introduction of such resistance among Enterobacteriaecae to this country.

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Section: Discussionmentioning

confidence: 99%

Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon

El-Herte

Araj

Matar

et al. 2012

J Infect Dev Ctries

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“…The frequent use of carbapenems, however, combined with the transmissibility of resistance determinants mediated by plasmids, transposons and gene cassettes, has contributed to the increase of carbapenem resistance by Enterobacteriaceae 2,3 . In countries such as the United States, Israel,Germany and Greece, carbapenemase-producing Enterobacteriaceae (CPE) had emerged and the dissemination of these multidrug-resistant pathogens had become a problem in clinical care of patients and in public health [4][5][6][7] . Invasive infections with these organisms have been associated with high rates of morbidity and mortality, due to their resistance to most available antimicrobial agents [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Characteristics and management of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemase in a tertiary hospital

Pang¹,

Jia²,

Song³

et al. 2016

Afr H. Sci.

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Background: The emergence of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemases is rare. We report an occurrence of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemases in a Chinese tertiary care hospital from November 2010 to December 2012. Methods: The clinical characteristics of 30 patients were described. The genetic relationship of isolates was determined by pulsed-field gel electrophoresis (PFGE). Carbapenemases were detected by modified Hodge test (MHT) and polymerase chain reactions (PCRs). Amplicons were sequenced and blasted to determine the genotype. Results: Most infected patients were from intensive care unit and had complex and serious underlying illnesses requiring mechanical ventilation. PFGE revealed that Klebsiella pneumoniae showed two major PFGE types. Two Klebsiella oxytoca had an indistinguishable PFGE pattern, while four Enterobacter cloacae were different strains. The sequencing studies showed Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemase in the 23 infected patients. The majority of patients had infections with the carbapenemase-producing Enterobacteriaceae (CPE) strain, most were successfully treated with a range of antibiotics and discharged. Conclusion: It is important to maintain a high index of suspicion to screen for carbapenemase-producing Enterobacteriaceae strains. Rapid identification of these strains and implementation of stringent procedures are the key to prevent major outbreaks in a hospital setting.

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“…Similarly, it has been shown that carbapenem resistance levels intensify when resistance encoding genes such as bla OXA-48 are combined with permeability defects [13].Yang et al demonstrated similar results, whereby they confirmed that the combination of SHV-1, CTXM-3, CTXM-14, TEM-1 or OXA-11 production reduced the expression of OMPK-35/36 resulting in increased MIC, which may or may not lead to increased resistance clinically [23].…”

Section: Discussionmentioning

confidence: 82%

Prevalence of carbapenem resistance encoding genes and corresponding MIC90 in enterobacteriaceae at a tertiary medical care center in Lebanon

Kissoyan¹,

Araj²,

Matar

2016

int. arab. j antimicrob. agents

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The threat of carbapenem-resistant Enterobacteriaceae in Lebanon: An update on the regional and local epidemiology

Cited by 41 publications

References 67 publications

Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon

Detection of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae producing NDM-1 in Lebanon

Characteristics and management of Enterobacteriaceae harboring IMP-4 or IMP-8 carbapenemase in a tertiary hospital

Prevalence of carbapenem resistance encoding genes and corresponding MIC90 in enterobacteriaceae at a tertiary medical care center in Lebanon

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