The threat to public health of hepatitis C

Lavanchy, Daniel

doi:10.1016/s0923-2516(97)89900-1

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Previous and more recent studies have reported regional prevalence estimates, but always considering a limited number of countries[ 6 , 8 - 13 ]. A more recent analysis, instead, estimates a global HCV prevalence, but provides only regional estimates[ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes

Petruzziello¹,

Marigliano²,

Loquercio³

et al. 2016

WJG

738

604

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AIMTo review Hepatitis C virus (HCV) prevalence and genotypes distribution worldwide.METHODSWe conducted a systematic study which represents one of the most comprehensive effort to quantify global HCV epidemiology, using the best available published data between 2000 and 2015 from 138 countries (about 90% of the global population), grouped in 20 geographical areas (with the exclusion of Oceania), as defined by the Global Burden of Diseases project (GBD). Countries for which we were unable to obtain HCV genotype prevalence data were excluded from calculations of regional proportions, although their populations were included in the total population size of each region when generating regional genotype prevalence estimates.RESULTSTotal global HCV prevalence is estimated at 2.5% (177.5 million of HCV infected adults), ranging from 2.9% in Africa and 1.3% in Americas, with a global viraemic rate of 67% (118.9 million of HCV RNA positive cases), varying from 64.4% in Asia to 74.8% in Australasia. HCV genotype 1 is the most prevalent worldwide (49.1%), followed by genotype 3 (17.9%), 4 (16.8%) and 2 (11.0%). Genotypes 5 and 6 are responsible for the remaining < 5%. While genotypes 1 and 3 are common worldwide, the largest proportion of genotypes 4 and 5 is in lower-income countries. Although HCV genotypes 1 and 3 infections are the most prevalent globally (67.0% if considered together), other genotypes are found more commonly in lower-income countries where still account for a significant proportion of HCV cases.CONCLUSIONA more precise knowledge of HCV genotype distribution will be helpful to best inform national healthcare models to improve access to new treatments.

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Section: Introductionmentioning

confidence: 99%

Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes

Petruzziello¹,

Marigliano²,

Loquercio³

et al. 2016

WJG

738

604

View full text Add to dashboard Cite

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Global epidemiology and genotype distribution of the hepatitis C virus infection

Gower¹,

Estes²,

Blach³

et al. 2014

Journal of Hepatology

1,720

1,602

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The treatment of chronic hepatitis C virus (HCV) infection has the potential to change significantly over the next few years as therapeutic regimens are rapidly evolving. However, the burden of chronic infection has not been quantified at the global level using the most recent data. Updated estimates of HCV prevalence, viremia and genotypes are critical for developing strategies to manage or eliminate HCV infection. To achieve this, a comprehensive literature search was conducted for anti-HCV prevalence, viraemic prevalence and genotypes for all countries. Studies were included based on how well they could be extrapolated to the general population, sample size and the age of the study. Available country estimates were used to develop regional and global estimates. Eighty-seven countries reported anti-HCV prevalence, while HCV viraemic rates were available for fifty-four countries. Total global viraemic HCV infections were estimated at 80 (64-103) million infections. Genotype distribution was available for ninety-eight countries. Globally, genotype 1 (G1) was the most common (46%), followed by G3 (22%), G2 (13%), and G4 (13%). In conclusion, the total number of HCV infections reported here are lower than previous estimates. The exclusion of data from earlier studies conducted at the peak of the HCV epidemic, along with adjustments for reduced prevalence among children, are likely contributors. The results highlight the need for more robust surveillance studies to quantify the HCV disease burden more accurately.

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The threat to public health of hepatitis C

Cited by 2 publications

References 19 publications

Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes

Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes

Global epidemiology and genotype distribution of the hepatitis C virus infection

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