The Thyro‐Hypophysial Syndrome.

Urinary Excretion of Calcium and 17‐Ketogenic Steroids in Hyperthyroidism

“…Sixteen were women and four men, their ages ranging from 18 to 76 years. In 11 of these cases there was exophthalmos with oedema of the eyelids (Syndromu thyeohypo~hysurium, STH) (18,19).…”

“…The regulatory influence of the anterior lobe of the pituitary gland and the hypothalamus on thyroid function, as well as the importance of pituitary factors in the development of exophthalmic goitre, has been well documented (7,8,18,30). The interrelationship between the corticotropic and exophthalmos-producing activity of the anterior pituitary has been demonstrated, for instance by the recent observation of a n exophthalmos-producing factor in the serum and pituitary of patients with Gushing's syndrome and acromegaly, which was shown to disappear after hypophysectomy or pituitary irradiation (26).…”