The thyroid follicle in man: Its normal and pathological configuration

Wilson, Gale E.

doi:10.1002/ar.1090370104

Cited by 29 publications

(4 citation statements)

References 24 publications

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“…However, the lumen of a new follicle and its interfollicular contact appear simultaneously. Our findings regarding the formation of new follicles in the rat thyroid gland support the findings made by other authors (Wilson, 1927;Kachalka, 1986). However, we believe that a new follicle is not necessarily separated from its maternal follicle during postnatal ontogenesis.…”

Section: Discussionsupporting

confidence: 93%

The epitheliomeral concept of the thyroid gland's structural organization

1996

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Background The permanent increase in the number of cases of different forms of thyroid pathology requires a deeper study of the thyroid structure and its morphogenetic processes. Methods The thyroid glands of Wistar rats were used in a composite study that involved standard light microscopy, semithin sections, silver staining, immunohistochemistry, morphometry, three‐dimensional analysis, and computer‐assisted three‐dimensional reconstruction. Results The absolute majority of follicles have from one to seven inter‐follicular contacts (C) with other neighbouring follicles. The surface of C makes up 32% of the follicular basal surface. In the central zone of 1‐μm‐thick sections, the relative quantity of C per follicle (0.44 ± 0.05) is 36% more than in the peripheral zone (0.28 ± 0.07; P < 0.05). The analysis of serial sections shows that 134 follicles have 133 C. Only three follicles are separate; four form pair groups, and others form groups that include up to 92 follicles. Follicles form linear chains with numerous branches. A three‐dimensional reconstruction demonstrates a spatial configuration of the parenchyma's elements. In C, the basement membrane is absent. Consequently, a group of interconnected follicles form a parenchymal compartment with a common basement membrane. We named these parenchymal compartments “epitheliomers.” Both the formation of new follicles and follicular fusion take place within the boundaries of the epitheliomer without violating the integrity of the compartment. The fusion of follicles is brought on by the destruction of the epithelium of C. Conclusions The authors put forward a new “epitheliomeral” concept with regard to the structural organization of the thyroid gland. © 1996 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 93%

The epitheliomeral concept of the thyroid gland's structural organization

1996

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“…Since the original discovery of the C cells many hypotheses have been proposed with regard to their nature and function. At one time or another they have been considered as tangential sections of groups of follicular cells (Wilson, 1927;Ludwig, 1953), cells originating from follicular cells (Altmann, 1940;Nonidez, 1932), cells dealing with the neoformation of follicles (wolfler, 1883;Florentin, 1929;Zechel, 1932;Baillif, 1937;Saito & Shibata, 1957), cells belonging to the system of Feyrter (Ponse, 1951), cells migrating to the parathyroid (Getzowa, 1907;Halpenny & Thompson, 1909), cells originating from embryonic structures such as the ultimobranchial body (Godwin, 1937), or thyroglossal duct (Dumont, 1956), neurosecretory cells (Sunder-Plassmann, 1939), and secretory cells (Baber, 1876;Takagi, 1922/23;Nonidez, 1931/2;Ohkubo, 1934;Geraldes Barba, 1944, 1946,1948,1950.…”

Section: Discussionmentioning

confidence: 99%

The Cytology and Cytochemistry of the “C” Cells in the Thyroid Gland of the Pig

Carvalheira

Pearse²

1967

Journal of the Royal Microscopical Society

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“…Although according to Wegelin (1926) it was difficult to establish the embryonal nature of the solid (interfollicular) cell masses Marine (1932) agreed th at the cells were potentially capable of growth and varying degrees of differentiation whenever a sufficient stimulus for increased thyroid activity was applied. On the other hand, Wilson (1927) believed th at there were no interfolli cular cells in the gland. Using wax reconstructions this author decided th at the solid and apparently interfollicular cell masses were really tangentially cut sections of follicles.…”

Section: -2mentioning

confidence: 99%

The cytochemistry of the thyroid C cells and their relationship to calcitonin

1966

Proc. R. Soc. Lond. B.

203

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(1) A population of cells exists in the thyroid gland (of the dog and other mammals) which is entirely distinct from the population of follicular or acinar cells. (2) The cells were originally described in 1877 by Baber, in the dog thyroid, and later by Hürthle (1894) and by Nonidez (1931). They are characterized cytochemieally by a content of basic protein or polypeptide, by argyrophilia, and by high α -glycerophosphate dehydrogenase. At the electron microscope level, their cytoplasm is seen to be filled with spherical vesicles 1500 to 2000°A in diameter, bounded by a single membrane, and their mitochondria are especially electron dense. (3) These cells, the C cells, respond to high blood calcium levels by increased secretion of the product contained in the spherical vesicles. (4) It is postulated that this product is thyrocalcitonin, the calcium regulating hormone of the thyroid gland. If this premise is correct the C cells constitute a new endocrine system.

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The thyroid follicle in man: Its normal and pathological configuration

Cited by 29 publications

References 24 publications

The epitheliomeral concept of the thyroid gland's structural organization

The epitheliomeral concept of the thyroid gland's structural organization

The Cytology and Cytochemistry of the “C” Cells in the Thyroid Gland of the Pig

The cytochemistry of the thyroid C cells and their relationship to calcitonin

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