The thyroid gland in the management of carcinoma of the larynx and laryngopharynx

Bahadur, Sudhir; Iyer, Subramania; Kacker, S. K.

doi:10.1017/s0022215100098480

Cited by 14 publications

(25 citation statements)

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“…As far as the neck is concerned, although we have not seen statistically significant difference among patients clinically NO and N1-3 in the genesis of recurrence in the tracheostoma area in our study (p=0.240), we have to stress the importance of paratracheal lymphnodes in larynx cancer reported by other authors, especially when the tumor involves the infraglottic region 4,6,13,23 . Lymphnode metastasis in head and neck tumors is the most important prognostic factor related to patient survival, especially when the primary tumor is located in the larynx, hypopharynx or upper esophagus.…”

Section: Discussioncontrasting

confidence: 75%

“…Based on these results, the authors advocate partial or total thyroidectomy in these cases 13,23 . Direct thyroid gland invasion may occur in transglottic tumors or supraglottis carcinomas because of tumor invasion through the thyroid cartilage or the cricothyroid membrane 24,25 .…”

Section: Discussionmentioning

confidence: 99%

“…Indirect or secondary thyroid gland involvement may also occur in subglottis or transglottic tumors because of lymphatic spread to the pre-laryngeal or Delphian node. All these examples mentioned, and if not considered during surgery may, with time, create unexpected tumor recurrence in the tracheostoma area in laryngectomized patients 23 . Total laryngectomies are usually carried out in a broad field, including pre-laryngeal muscles and the adjacent soft tissue.…”

Section: Discussionmentioning

confidence: 99%

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Recorrência na área do traqueostoma após laringectomia total

Sartini

Fava

Faria

2007

Rev. Bras. Otorrinolaringol.

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St oma recurrence after total laryngectomy is one of the most severe developments of squamous cell carcinoma of the larynx. Risk factors most strongly implicated in stoma recurrence have been subglottic invasion by the laryngeal tumor and tracheotomy prior to laryngectomy. Aim: Study the clinical findings of patients who underwent total laryngectomy and evaluate the probable risk factors to the development of stoma recurrence. Study design: Descriptive and retrospective study Materials and methods: We studied data from 47 patients who underwent total laryngectomy for the treatment of laryngeal cancer between 1995 and 2004 and evaluated recurrences and risk factors. Results: Stoma recurrence developed in 10.6 per cent of them(5 cases). There was no significant correlation between stoma recurrence and subglottic invasion or prior tracheotomy. Conclusion: Stoma recurrence still is one of the most lethal developments associated to laryngeal cancer. In the present study it was not possible to identify factors related to this recurrence. Further studies with a larger sample and a longer follow-up period are necessary to better understand this condition.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Recorrência na área do traqueostoma após laringectomia total

Sartini

Fava

Faria

2007

Rev. Bras. Otorrinolaringol.

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“…5,15 Likewise, in our series, we observed thyroid gland involvement in 47 per cent of the cases in which the post-cricoid region was implicated ( p < 0.05). In the study by Hilly et al there was cartilage invasion in 10 of 11 cases with thyroid gland involvement, and all tumours were in proximity to (or in contact with) areas of calcification and ossification.…”

Section: Discussionsupporting

confidence: 66%

Thyroid gland involvement in carcinoma of the hypopharynx

Joshi

Nair²,

Chaturvedi

et al. 2014

J. Laryngol. Otol.

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“…1 Tedavi öncesi fark edilemeyen hipotirodi faringokutanöz fistüllere, geç yara iyileflmesine, depresyona, konuflma rehabilitasyonunda güçlükle-re ve kardiyak morbiditeye neden olmaktad›r. 2,3 Bu duruma neden olabilecek baz› patofizyolojik mekanizmalar öne sürülmüfltür. Örne¤in boyun diseksiyonu s›ras›nda tiroid bezin vasküler beslenmesi isteyerek veya istemeyerek zarar görebilir.…”

Section: Giriflunclassified

Larenks kanserli hastalarda cerrahi ve radyoterapi sonrası tiroid fonksiyonlarının prospektif olarak değerlendirilmesi

2008

Turk Arch Otolaryngol

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ÖzetAmaç: Larenks kanseri nedeniyle tedavi gören hasta grubunda, gerek cerrahiye gerekse radyoterapiye ba¤l› geliflen hipotiroidi s›k görülen ancak gözden kaçabilen bir komplikasyondur. Yara iyileflmesinde gecikme, fistül geliflimi ve kardiyovasküler yan etkiler gibi olumsuz durumlara neden olabilmektedir. Bu çal›flmada larenks kanseri nedeniyle larenjektomi ve radyoterapi tedavisi alan hastalarda tiroid fonksiyonlar›n›n de¤erlendirilmesi ve hipotiroidi geliflmesinde etkili risk faktörlerinin belirlenmesi amaçlanm›flt›r.Yöntem: Larenjektomi ve radyoterapi tedavisi uygulanan 75 hastan›n tiroid fonksiyonlar› prospektif olarak cerrahi öncesi, radyoterapi öncesi ve cerrahi sonras› düzenli aral›klarla de¤er-lendirildi. Tiroid fonksiyonlar› olarak TSH, serbest T3, serbest T4, Anti-TPO ve Anti-TG bak›ld›. Tiroid disfonksiyonu yapabilecek risk faktörleri multivaryans analiz ile de¤erlendirildi. Bulgular: Ortalama yafl› 59.4 olan hastalar›n hepsi erkekti ve ortalama takip süresi 28.6 ay olarak bulundu. Hipotiroidi geliflme insidans› %49.3'tü ve hipotiroidinin ortaya ç›k›fl süresi tedavi bitiminden ortalama 6 ay sonra olarak tespit edildi. Radyoterapi dozu, lerenjektomi tipi, boyun diseksiyonunun geniflli¤i, tiroid lobektomi uygulanmas› ve spesimenlerde tiroidit saptanmas› tiroid disfonksiyonu için önemli risk faktörleri olarak bulundu.Sonuç: Özellikle risk faktörleri tafl›yan tedavi görmüfl larenks kanserli hastalar›n tiroid fonksiyonlar› aç›s›ndan periyodik olarak kontrol edilmesi, erken tan› ve tedavi için önemlidir. Bu hastalarda CPAP kullan›m› ile beraber bu bulgular›nda k›sa sü-rede düzelmeye bafllad›¤› görülmüfltür.

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The thyroid gland in the management of carcinoma of the larynx and laryngopharynx

Cited by 14 publications

References 3 publications

Recorrência na área do traqueostoma após laringectomia total

Recorrência na área do traqueostoma após laringectomia total

Thyroid gland involvement in carcinoma of the hypopharynx

Larenks kanserli hastalarda cerrahi ve radyoterapi sonrası tiroid fonksiyonlarının prospektif olarak değerlendirilmesi

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