The timing and sequence of events in the development of the human nervous system during the embryonic period proper

Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses

“…We had access to specimens from 10 human embryos that corresponded to 4.5 to 8 postovulatory weeks (provided by Dr. Zecevic) and 10 fetuses aged from 10 to 24 weeks (O'Rahilly and Gardner, 1971;Puelles and Verney, 1998;Verney et al, 1996;Zecevic and Verney, 1995). These specimens were obtained in Yugoslavia and France from medically indicated or spontaneous abortions following the recommendations of the French (CCNESVS, 90 294) and Yugoslavian Ethical Committees.…”

Development and differentiation of pituitary cells

“…In man, the hypothalamus is the first region of the forebrain to differentiate (O'Rahilly and Gardner, 1971). From 4 weeks, the hypothalamic sulcus, chiasmatic plate, and mammillary bodies are recognizable.…”

“…From 4 weeks, the hypothalamic sulcus, chiasmatic plate, and mammillary bodies are recognizable. From the 6th week, the first specific nuclei and fibre tracts appear and develop (O'Rahilly and Gardner, 1971). Table 2 gives the timing of appearance of the different hypothalamic hormones in man, sheep, and rat.…”

Development of the brain in staged embryos of the long-tailed monkey (Macaca fascicularis)

“…Despite these observations on the brain and its derivatives, there is no systematic description of the morphogenesis of the CNS in this species. Early development of the brain in the primate embryo has been well documented in the human (BARTELMEZ & DEKABAN, 1962;O'RAHILLY & GARDNER, 1971;O'RAHILLY & MULLER, 1984, 1994, baboon (DAVIGNON et al, 1980), and rhesus monkey (DAvIGNON et al, 1980;GRmNAU & GEIJSBERTS, 1985).…”