The timing of first meiotic prophase in oocytes from female domestic dogs (<i>Canis familiaris</i>)

Freixa, L.; Garcı́a, M.; Egozcue, J.

doi:10.1139/g87-036

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…In contrast, meiosis in female dogs begins later, in the neonatal period. While recombination is complete prior to ovulation in humans, dogs ovulate immature oocytes, after which meiosis must complete before the oocyte becomes fertile, around 48 hr after ovulation (Freixa et al 1987; Chastant-Maillard et al 2011). …”

Section: Discussionmentioning

confidence: 99%

A Pedigree-Based Map of Recombination in the Domestic Dog Genome

Campbell

Bhérer

Morrow

et al. 2016

G3 Genes|Genomes|Genetics

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Meiotic recombination in mammals has been shown to largely cluster into hotspots, which are targeted by the chromatin modifier PRDM9. The canid family, including wolves and dogs, has undergone a series of disrupting mutations in this gene, rendering PRDM9 inactive. Given the importance of PRDM9, it is of great interest to learn how its absence in the dog genome affects patterns of recombination placement. We have used genotypes from domestic dog pedigrees to generate sex-specific genetic maps of recombination in this species. On a broad scale, we find that placement of recombination events in dogs is consistent with that in mice and apes, in that the majority of recombination occurs toward the telomeres in males, while female crossing over is more frequent and evenly spread along chromosomes. It has been previously suggested that dog recombination is more uniform in distribution than that of humans; however, we found that recombination in dogs is less uniform than in humans. We examined the distribution of recombination within the genome, and found that recombination is elevated immediately upstream of the transcription start site and around CpG islands, in agreement with previous studies, but that this effect is stronger in male dogs. We also found evidence for positive crossover interference influencing the spacing between recombination events in dogs, as has been observed in other species including humans and mice. Overall our data suggests that dogs have similar broad scale properties of recombination to humans, while fine scale recombination is similar to other species lacking PRDM9.

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Section: Discussionmentioning

confidence: 99%

A Pedigree-Based Map of Recombination in the Domestic Dog Genome

Campbell

Bhérer

Morrow

et al. 2016

G3 Genes|Genomes|Genetics

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“…In case of oocytes, observations of SCs can be made on material collected from fetal ovaries. Although there are species in which pachytene substage appears in ovaries shortly after birth, that is, the dog ( Freixa et al 1987;Lechniak et al 1997) and some rodent species (Singh et al 1993), investigations of chromosome pairing in breeding females are impossible. Only a few studies have been carried out on synaptic behavior in fetal bovine oocytes (Jung 1991;Koykul and Basrur 1994a;Świtoń ski and Basrur 1992).…”

Section: Studies Of Synaptonemal Complexes In Farm Mammals-a Review M ś Witoń Ski and G Stranzingermentioning

confidence: 99%

Studies of synaptonemal complexes in farm mammals - a review

Świtoński¹,

Stranzinger²

1998

Journal of Heredity

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For the last 10 years extensive studies of synaptonemal complexes in farm mammals were carried out. In this article a survey of the obtained results is presented. Studies on synaptic behavior of chromosomes at pachytene substage of meiotic prophase I in carriers of centric fusions (cattle, sheep, goat, pig, and blue fox) showed that the trivalent is rarely involved in an association with the sex bivalent. In carriers of reciprocal translocations (pig and cattle) a wide range of synaptic configurations were found. Besides the expected cross-shaped quadrivalent, the following configurations were observed: open quadrivalent, trivalent plus univalent, and two heteromorphic bivalents. The latter configurations were quite frequently involved in the association with XY bivalent. Studies of synaptonemal complexes in interspecies hybrids (cattle x zebu, river x swamp buffalo, blue fox x silver fox) revealed a wide range of synaptic disturbances. Cases of pericentric inversions, aneuploidy, and chromosomal polymorphisms are also reviewed. This survey shows that synaptonemal complex analysis is a very useful tool in studies on causes of altered fertility in carriers of abnormal chromosome complement.

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The timing of first meiotic prophase in oocytes from female domestic dogs (Canis familiaris)

Cited by 2 publications

References 5 publications

A Pedigree-Based Map of Recombination in the Domestic Dog Genome

A Pedigree-Based Map of Recombination in the Domestic Dog Genome

Studies of synaptonemal complexes in farm mammals - a review

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