The timing of prophylactic administration of antibiotics and the risk of surgical‐wound infection

Johnson, Jane Helen

doi:10.1016/s0001-2092(07)68699-2

Cited by 3 publications

(3 citation statements)

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“…Synthetic vascular prosthesis implantation generates particular microenvironments and conditions that can promote bacterial wound invasion and biofilm formation; this latter functionality defends enclosed bacteria from antibiotic therapy and host defense [ 38 ]. To reduce or eliminate the bacterial colonization of damaged tissues, an antibiotic prophylaxis should be administered for effective drug concentrations in tissue at the surgical site before surgery commences.…”

Section: Pre-operative Antibiotic Therapymentioning

confidence: 99%

“…To reduce or eliminate the bacterial colonization of damaged tissues, an antibiotic prophylaxis should be administered for effective drug concentrations in tissue at the surgical site before surgery commences. Therefore, the administration of pre-operative antibiotic therapy is advisable 60 min before surgery, and also in additional intraoperative doses if the operation lasts more than 4 h and/or more than 1500 cc blood is lost [ 25 , 38 ].…”

Section: Pre-operative Antibiotic Therapymentioning

confidence: 99%

“…To combat SSIs in vascular surgery, the prophylaxes of choice are primarily first or second-generation cephalosporins, as they are low-cost options (the most common prophylaxis is cefazolin). Vancomycin or clindamycin appear to be preferentially used for patients with β-lactam allergy [ 38 ].…”

Section: Pre-operative Antibiotic Therapymentioning

confidence: 99%

See 2 more Smart Citations

Groin Surgical Site Infection in Vascular Surgery: Systemic Review on Peri-Operative Antibiotic Prophylaxis

Amato¹,

Compagna

Vivo

et al. 2022

Antibiotics

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Objectives: Surgical site infections (SSIs) in lower extremity vascular surgeries, post-groin incision, are not only common complications and significant contributors to patient mortality and morbidity, but also major financial burdens on healthcare systems and patients. In spite of recent advances in pre- and post-operative care, SSI rates in the vascular surgery field remain significant. However, compliant antibiotic therapy can successfully reduce the SSI incidence pre- and post-surgery. Methods: In October 2021, we conducted a systematic literature review using OVID, PubMed, and EMBASE databases, centered on studies published between January 1980 and December 2020. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta Analyses checklist. Inclusion/exclusion criteria have been carefully selected and reported in the text. For analyses, we calculated 95% confidence intervals (CI) and weighted odds ratios to amalgamate control and study groups in publications. We applied The Cochrane Collaboration tool to assess bias risk in selected studies. Results: In total, 592 articles were identified. After the removal of duplicates and excluded studies, 36 full-texts were included for review. Conclusions: The review confirmed that antibiotic therapy, administered according to all peri-operative protocols described, is useful in reducing groin SSI rate in vascular surgery.

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Section: Pre-operative Antibiotic Therapymentioning

confidence: 99%

Section: Pre-operative Antibiotic Therapymentioning

confidence: 99%