The timing of rheumatoid factor seroconversions

Aho, Kimmo; Palosuo, Timo; Raunio, V.; Tuomi, Tiinamaija

doi:10.1002/art.1780300623

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…Among the at-risk seronegative subjects, 9 of 23 (39%) were positive for at least 1 autoantibody in their sputum, although in paired analyses with sputum and serum, only the proportion of anti-CCP3.1 positivity in their sputum was statistically Among the at-risk seropositive subjects, a higher proportion were positive for autoantibodies in their serum compared to sputum, although, when comparing each autoantibody in sputum versus serum within an individual, some individuals were positive for specific autoantibodies only in their sputum ( Figure 2B). Additionally, there was no significant difference between the numbers of autoantibodies in sputum and serum in this group (median [range] 1 [0-6] in sputum versus 2 [1][2][3] in serum; P ϭ 0.13).…”

Section: Subject Demographics Subjects' Characteristics Are Presentementioning

confidence: 73%

“…The finding of serum elevations of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs) prior to the symptomatic onset of inflammatory arthritis in rheumatoid arthritis (RA) suggests that RA-related autoimmunity may be initiated outside of the joints (1)(2)(3)(4)(5). Although the anatomic site of initiation of RA-related autoantibody production is unknown, emerging data, including the identification of elevations of IgA autoantibodies in subjects prior to the onset of symptomatic RA, suggest that initiation may occur at a mucosal site (6)(7)(8)(9).…”

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confidence: 99%

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Sputum Autoantibodies in Patients With Established Rheumatoid Arthritis and Subjects at Risk of Future Clinically Apparent Disease

Willis

Demoruelle

Derber

et al. 2013

Arthritis & Rheumatism

195

158

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Objective To evaluate the generation of rheumatoid arthritis (RA)–related autoantibodies in the lung. Methods Simultaneous collection of serum and induced sputum was performed in 21 healthy controls, 49 at-risk subjects without inflammatory arthritis but at risk of RA due to family history or seropositivity for anti–citrullinated protein antibodies, and 14 subjects with early RA. Samples were tested for anti–cyclic citrullinated peptide 2 (anti-CCP2), anti-CCP3, anti-CCP3.1, rheumatoid factor isotypes IgM, IgG, and IgA, and total IgM, IgG, and IgA. Results One or more autoantibodies were present in sputum of 39% of at-risk seronegative subjects, 65% of at-risk seropositive subjects, and 86% of subjects with early RA. In at-risk seronegative subjects, the rate of anti-CCP3.1 positivity and the median number of autoantibodies were elevated in sputum versus serum. In subjects with early RA, the rate of positivity for several individual autoantibodies and the median number of autoantibodies were higher in serum than in sputum. Results in at-risk seropositive subjects were intermediate between these groups. In at-risk subjects with autoantibody positivity in sputum, the ratios of autoantibody to total Ig were higher in sputum than in serum, suggesting that these autoantibodies are generated or sequestered in the lung. Conclusion RA-related autoantibodies are detectable in sputum in subjects at risk of RA and in subjects with early RA. In a subset of at-risk subjects, the presence of sputum autoantibodies in the absence of seropositivity, and the increased autoantibody-to–total Ig ratios in sputum, suggest that the lung may be a site of autoantibody generation in the early development of RA. These findings suggest an important role of the lung in the pathogenesis of RA.

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Section: Subject Demographics Subjects' Characteristics Are Presentementioning

confidence: 73%

mentioning

confidence: 99%

Sputum Autoantibodies in Patients With Established Rheumatoid Arthritis and Subjects at Risk of Future Clinically Apparent Disease

Willis

Demoruelle

Derber

et al. 2013

Arthritis & Rheumatism

195

158

View full text Add to dashboard Cite

show abstract

“…13 Support for diagnosis of RA comes from laboratory tests, mainly for RF. A significantly raised RF indicates those with increased susceptibility to developing RA, [11][12][13][14] and thus, is sensitive in the early diagnosis of patients with suspected symptoms of RA. 15 Newer markers of RA (AKA, APF, anti-RA33) were only used by a small proportion of the respondents, but have been increasingly used in the past three years.…”

Section: Discussionmentioning

confidence: 99%