The TIR‐NBS protein TN13 associates with the CC‐NBS‐LRR resistance protein RPS5 and contributes to RPS5‐triggered immunity in Arabidopsis

Cai, Huiren; Wang, Wei; Lu, Rui; Han, Libo; Luo, Mingyu; Liu, Na; Tang, Dingzhong

doi:10.1111/tpj.15345

Cited by 14 publications

(8 citation statements)

References 57 publications

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“…Accumulation of RBA1 is not only induced by HopBA1, but is also broadly correlated with HR cell death triggered by NLRs (Nishimura et al, 2017), and a role of RBA1 in immune signaling mediated by the CNL ZAR1 has been shown recently (Martel et al, 2020). Consistent with a contribution of TIRs in CNL-mediated ETI, more recent data revealed a direct functional link between AtTN13 and RPS5 in Arabidopsis (Cai et al, 2021). These results agree with gene expression profiling analysis revealing biotic stress-induced expression of TIR-only and TN genes (Nandety et al, 2013).…”

Section: Multiple Potential Functions Of 2′3′-camp/cgmpmentioning

confidence: 73%

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

Song

Tan

et al. 2022

Cell

136

132

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Section: Multiple Potential Functions Of 2′3′-camp/cgmpmentioning

confidence: 73%

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

Song

Tan

et al. 2022

Cell

136

132

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“…Interestingly, TN proteins also appear to function in CNL-mediated immunity. Both TN13 and TN21 interact with a CNL, RPS5, and the TN13:RPS5 complex specifically confers resistance to the P. syringae DC3000 carrying effector avrPphB (Cai et al 2021 ).…”

Section: Tir Domain-containing Proteins In Flowering Plantsmentioning

confidence: 99%

Structural basis of NLR activation and innate immune signalling in plants

et al. 2022

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Animals and plants have NLRs (nucleotide-binding leucine-rich repeat receptors) that recognize the presence of pathogens and initiate innate immune responses. In plants, there are three types of NLRs distinguished by their N-terminal domain: the CC (coiled-coil) domain NLRs, the TIR (Toll/interleukin-1 receptor) domain NLRs and the RPW8 (resistance to powdery mildew 8)-like coiled-coil domain NLRs. CC-NLRs (CNLs) and TIR-NLRs (TNLs) generally act as sensors of effectors secreted by pathogens, while RPW8-NLRs (RNLs) signal downstream of many sensor NLRs and are called helper NLRs. Recent studies have revealed three dimensional structures of a CNL (ZAR1) including its inactive, intermediate and active oligomeric state, as well as TNLs (RPP1 and ROQ1) in their active oligomeric states. Furthermore, accumulating evidence suggests that members of the family of lipase-like EDS1 (enhanced disease susceptibility 1) proteins, which are uniquely found in seed plants, play a key role in providing a link between sensor NLRs and helper NLRs during innate immune responses. Here, we summarize the implications of the plant NLR structures that provide insights into distinct mechanisms of action by the different sensor NLRs and discuss plant NLR-mediated innate immune signalling pathways involving the EDS1 family proteins and RNLs.

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“…Apart from “full-length” TNLs, C-terminally truncated versions without leucine-rich repeats exist. These TN proteins are thought to co-operate with TNLs as complexes ( Zhang and Gassmann, 2003 ; Liang et al, 2019 ; Cai et al, 2021 ; Chen et al, 2021 ).…”

Section: Plant Immunity At a Glancementioning

confidence: 99%

Plant autoimmunity—fresh insights into an old phenomenon

et al. 2021

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The plant immune system is well equipped to ward off the attacks of different types of phytopathogens. It primarily relies on two types of immune sensors - plasma membrane-resident receptor-like kinases (RLKs) and intracellular nucleotide-binding domain leucine-rich repeat receptors (NLRs) that engage preferentially in pattern- and effector-triggered immunity, respectively. Delicate fine-tuning, in particular of the NLR-governed branch of immunity, is key to prevent inappropriate and deleterious activation of plant immune responses. Inadequate NLR allele constellations, such as in the case of hybrid incompatibility, and the mis-activation of NLRs or the absence or modification of proteins guarded by these NLRs can result in the spontaneous initiation of plant defense responses and cell death – a phenomenon referred to as plant autoimmunity. Here we review recent insights augmenting our mechanistic comprehension of plant autoimmunity. The recent findings broaden our understanding regarding hybrid incompatibility, unravel candidates for proteins likely guarded by NLRs and underline the necessity for the fine-tuning of NLR expression at various levels to avoid autoimmunity. We further present recently emerged tools to study plant autoimmunity and draw a cross-kingdom comparison to the role of NLRs in animal autoimmune conditions.

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The TIR‐NBS protein TN13 associates with the CC‐NBS‐LRR resistance protein RPS5 and contributes to RPS5‐triggered immunity in Arabidopsis

Cited by 14 publications

References 57 publications

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

Structural basis of NLR activation and innate immune signalling in plants

Plant autoimmunity—fresh insights into an old phenomenon

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