The toll-like receptor family protein RP105/MD1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14

Murofushi, Yo; Villena, Julio; Morie, Kyoko; Kanmani, Paulraj; Tohno, Masanori; Shimazu, Tomoyuki; Aso, Hisashi; Suda, Yoshihito; Hashiguchi, Kenji; Saito, Tadao; Kitazawa, Haruki

doi:10.1016/j.molimm.2014.10.027

Cited by 78 publications

(66 citation statements)

References 41 publications

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“…Studies that evaluated the effects of probiotic strains on immune responses demonstrate that probiotic-mediated protection against pathogen-induced inflammation, in part, from maintaining the balance of proinflammatory and anti-inflammatory cytokines production in immune cells [12, 21–24]. L. acidophilus , one of the popular probiotics, has been confirmed its role of inflammatory regulation in human MKN45 cells [22], intestinal epithelial cells [23] and in piglets [4].…”

Section: Discussionmentioning

confidence: 99%

“…For examples, IL-8 has been associated with pathogen-induced alterations of tight junctions [25, 26], as well as TNF-α has remarkable functional duality that is strongly engaged in both tissue regeneration and destruction [13]. Several studies in vitro have shown that L. acidophilus is able to modulate the production of proinflammatory cytokines, including IL-8, TNF-α and IL-6 in intestinal epithelial cells [8, 12, 21, 23, 27]. Here, we observed significant down-regulated proinflammatory cytokines by L. acidophilus including IL-1β, IL-8 and TNF-α in piglets challenged with ETEC and a remarkable rise of anti-inflammatory cytokine IL-10 production .…”

Section: Discussionmentioning

confidence: 99%

“…Similar results were found in other LAB. L. plantarum N14 (LP14) regulates the production of proinflammatory cytokines from PIEs in response to ETEC challenge via TLR2 and TLR4 [21]. L. delbrueckii subsp.…”

Section: Discussionmentioning

confidence: 99%

“…Probiotic L. acidophilus is reported to decrease Salmonella-induced NF-κB activation in human intestinal Caco-2 cells [30]. Experiments in demonstrated that L. plantarum N14 (LP14) strongly activated NF-κB via RP105 and TLR2 in ETEC-infected PIE cells [21]. Ld strain and its APS can inhibit ETEC triggered mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) activation in PIE cells [28].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, continuously up-regulation of A20, Tollip, and SIGIRR plays a major part in the anti-inflammatory activity of L. casei MEP221114 in poly(I:C)-stimulated PIE cells [35]. The increased level of TLRs pathway negative regulators can also be found in other LAB which can alleviate inflammatory damages, such as L. plantarum [21], Ld, APS and NPS [28]. Consistently, the results here showed that L. acidophilus obviously up-regulated mRNA expression level of negative regulator Tollip and Bcl-3 in spleen post ETEC infection.…”

Section: Discussionmentioning

confidence: 99%

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Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets

Zhang

Chen

et al. 2016

BMC Microbiol

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BackgroundA newly isolated L. acidophilus strain has been reported to have potential anti-inflammatory activities against lipopolysaccharide (LPS) challenge in piglet, while the details of the related inflammatory responses are limited. Here we aimed to analysis the ability of L. acidophilus to regulate inflammatory responses and to elucidate the mechanisms involved in its anti-inflammatory activity.ResultsThe ETEC (enterotoxigenic Escherichia coli) K88-induced up-regulations of IL-1β, IL-8 and TNF-α were obviously inhibited by L. acidophilus while IL-10 was significantly increased. Moreover, L. acidophilus down-regulated pattern recognition receptors TLR (Toll-like receptor) 2 and TLR4 expression in both spleen and mesenteric lymph nodes of ETEC-challenged piglets, in accompanied with the reduced phosphorylation levels of nuclear factor kappa B (NF-κB) p65 and mitogen-activated protein kinase (MAPK) p38 as well in spleen of ETEC-infected piglets. Furthermore, L.acidophilus significantly increased the expression of the negative regulators of TLRs signaling, including Tollip, IRAK-M, A20 and Bcl-3 in spleen of ETEC-challenged piglets.ConclusionsOur findings suggested that L. acidophilus regulated inflammatory response to ETEC via impairing both NF-κB and MAPK signaling pathways in piglets.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets

Zhang

Chen

et al. 2016

BMC Microbiol

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Potential of fermented foods and their metabolites in improving gut microbiota function and lowering gastrointestinal inflammation

Padhi,

Sarkar,

Sahoo

et al. 2024

J Sci Food Agric

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Foods prepared using microbial conversion of major and minor food components, which are otherwise known as fermented foods continue to impact human health. The live microorganisms and transformed metabolites can also have a deep influence on the gut microbiota, the multifaceted population of microorganisms dwelling inside the gut play a key role in wellbeing of an individual. The probiotic strains delivered through the consumption of fermented food and other bioactive components such as polyphenolic metabolites, bioactive peptides, short‐chain fatty acids and others including those produced via gut microbiota mediated transformations have been proposed to balance the gut microbiota diversity and activity, and also to regulate the inflammation in the gut. However, little is known about such effects and only a handful of fermented foods have been explored to date. We herein review the recent knowledge on the dysbiotic gut microbiota linking to major gut inflammatory diseases. Also, evidences that fermented food consumption modulates the gut microbiota, and its impact on the gut inflammation and inflammatory diseases have been discussed. © 2024 Society of Chemical Industry.

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In vitro antifungal, probiotic, and antioxidant functional properties of a novel Lactobacillus paraplantarum isolated from fermented dates in Saudi Arabia

Arasu

Al-Dhabi

2017

J Sci Food Agric

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The toll-like receptor family protein RP105/MD1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14

Cited by 78 publications

References 41 publications

Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets

Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets

Potential of fermented foods and their metabolites in improving gut microbiota function and lowering gastrointestinal inflammation

In vitro antifungal, probiotic, and antioxidant functional properties of a novel Lactobacillus paraplantarum isolated from fermented dates in Saudi Arabia

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