The Topographic Effect of Zinc Oxide Nanoflowers on Osteoblast Growth and Osseointegration

Park, Jung Kyu; Kim, Yong-Jin; Yeom, Junseok; Jeon, Jihyun; Yi, Gyu‐Chul; Je, Jung Ho; Hahn, Sei Kwang

doi:10.1002/adma.201002255

Cited by 119 publications

(75 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Actually, many types of nanostructures such as nanotubes [22], nanorods [23], nanoflowers [24], and nanogratings [25] have been shown to have improved osseointegration ability When developing antibacterial coatings by incorporating antibacterial agents such as Ag, it is imperative that the cytocompatibility of the Ti implant is compromised. We have noticed that the existence of Ag in the Ti coatings prepared by magnetron sputtering can modulate the structure of the columnar crystals and the effects depend on the Ag concentration [26].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured titanium–silver coatings with good antibacterial activity and cytocompatibility fabricated by one-step magnetron sputtering

Bai

Hang

Gao

et al. 2015

Applied Surface Science

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Nanostructured titanium–silver coatings with good antibacterial activity and cytocompatibility fabricated by one-step magnetron sputtering

Bai

Hang

Gao

et al. 2015

Applied Surface Science

View full text Add to dashboard Cite

“…On the contrary, it was reported that the enhanced cell adhesion, proliferation and differentiation on ZnO nanoflowers ( Figure 5 (B)) [57]. In this work, the ZnO nanoflowers were also grown by the hydrothermal methods on the micro-patterned ZnO surface.…”

Section: Zinc Oxide Nanowiresmentioning

confidence: 72%

Synthetic nanowire/nanotube-based solid substrates for controlled cell growth

Baik

Namgung

et al. 2014

Nano Convergence

View full text Add to dashboard Cite

The behaviour of cells can be controlled by various microenvironments such as nanostructured cell-culture substrates with controlled nanotopography and chemical properties. One of promising substrates for controlled cell growth is a solid substrate comprised of synthetic one-dimensional nanostructures such as polymer nanofibers, carbon-based nanotubes/nanofibers, and inorganic nanowires. Such nanotube/nanowire structures have a similar dimension as extracellular matrix fibers, and their nanotopography and chemical properties can be easily controlled, which expands their possible applications in controlling the growth and differentiation of cells. This paper provides a concise review on the recent applications of solid substrates based on synthetic nanowires/nanotubes for controlled cell growth and differentiation.

show abstract

“…For example, hydroxyapatite (HA) nanoneedles and nanofibers, 17 quasi-aligned TiC and TiO 2 nanowires, 18 and randomly oriented and upright SiO 2 and ZnO nanorods 19 inhibited adhesion and spreading of cells. In contrast, the other lines revealed that ZnO nanoflowers, 20 gold-coated silicon nanopillars, 21 and Co-Cr nanopillars 22 improve the cell adhesion compared to the corresponding 2D counterparts. Therefore, it is necessary to construct a nanopatterned surface on the implant, which would favor positive interactions with osteoblasts.…”

Section: Introductionmentioning

confidence: 96%

“…8 Cell-material interactions depend on the surface properties of the material, such as chemistry, 2,9-11 surface energy, 2,12 roughness, 13 and topography. [14][15][16][17][18][19][20][21][22] Recent works demonstrated that three-dimensional (3D) nanotopography could influence cell adhesion; however, conflicting results have been reported. For example, hydroxyapatite (HA) nanoneedles and nanofibers, 17 quasi-aligned TiC and TiO 2 nanowires, 18 and randomly oriented and upright SiO 2 and ZnO nanorods 19 inhibited adhesion and spreading of cells.…”

Section: Introductionmentioning

confidence: 99%

Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings

Zhou¹,

Han²,

Lu³

2014

IJN

View full text Add to dashboard Cite

The process in which nanostructured surfaces mediate cell adhesion is not well understood, and may be indirect (via protein adsorption) or direct. We prepared Sr-doped hydroxyapatite (Sr 1 -HA) 3D nanorods (with interrod spacing of 67.3±3.8, 95.7±4.2, and 136.8±8.7 nm) and 2D nanogranulate patterned coatings on titanium. Employing the coatings under the same surface chemistry and roughness, we investigated the indirect/direct role of Sr 1 -HA nanotopographies in the regulation of osteoblast adhesion in both serum-free and serum-containing Dulbecco’s Modified Eagle/Ham’s Medium. The results reveal that the number of adherent cells, cell-secreted anchoring proteins (fibronectin, vitronectin, and collagen), vinculin and focal adhesion kinase (FAK) denoted focal adhesion (FA) contact, and gene expression of vinculin, FAK, and integrin subunits (α 2 , α 5 , α v , β 1 , and β 3 ), undergo significant changes in the inter-nanorod spacing and dimensionality of Sr 1 -HA nanotopographies in the absence of serum; they are significantly enhanced on the <96 nm spaced nanorods and more pronounced with decreasing interrod spacing. However, they are inhibited on the >96 nm spaced nanorods compared to nanogranulated 2D topography. Although the adsorption of fibronectin and vitronectin from serum are higher on 136.8±8.7 nm spaced nanorod patterned topography than nanogranulated topography, cell adhesion is inhibited on the former compared to the latter in the presence of serum, further suggesting that reduced cell adhesion is independent of protein adsorption. It is clearly indicated that 3D nanotopography can directly modulate cell adhesion by regulating integrins, which subsequently mediate anchoring proteins’ secretion and FA formation rather than via protein adsorption.

show abstract

The Topographic Effect of Zinc Oxide Nanoflowers on Osteoblast Growth and Osseointegration

Cited by 119 publications

References 21 publications

Nanostructured titanium–silver coatings with good antibacterial activity and cytocompatibility fabricated by one-step magnetron sputtering

Nanostructured titanium–silver coatings with good antibacterial activity and cytocompatibility fabricated by one-step magnetron sputtering

Synthetic nanowire/nanotube-based solid substrates for controlled cell growth

Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings

Contact Info

Product

Resources

About