The Toxic Effects of Paraquat (PQ) on Body Weights and  Haematological Parameters in Male Albino Wistar Rats and its Amelioration with Vitamin C

The main objective of the experiment is aimed to examine the impact of paraquat dichloride on the body weights of adult male Wistar rats as well as in their haematological tissues. The total number of male Wistar rats was 48 and was divided into 4 groups of 12 each. The 1st group (Test 1) served as control. The other three groups served as experimental groups in which the paraquat dichloride was administered. The experimental groups which are 2nd group (Test 2), 3rd group (Test 3) and 4th group (Test 4) received doses of paraquat dichloride of 10 mg/kg b.wt/per oral/day, 20 mg/kg b.wt/per oral/day and 40 mg/kg b.wt/per oral/day respectively. The experiment was carried out for a time duration of 42 days. The mean values of body weights, erythrocyte indices, total erythrocyte count (TEC), total leucocyte count (TLC) and Hb concentrations were significantly (P<0.05) decreased in Test 2, 3 and 4 rats, excluding packed cell volume (PCV), which in comparison to the control groups. Outcomes and observations from hematological parameters and bone marrow revealed the toxicity of paraquat dichloride to hematological tissues resulting in anemia and bone marrow hypoplasia which eventually leads to failure of the bone marrow and extensively hematopoietic system of adult male Wistar rats following long term exposure and high concentration.

Section: Haematology Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of paraquat dichloride on adult male wistar rat. an approach in the toxicity of body weights and hematological tissues

Edo¹

2022

“…30,31 It is seen to be highly reactive and vulnerable to free radicals and specifically reactive oxygen species as a result of possessing sulphuric and unsaturated molecules, amino acids such as phenylalanine, mitonin, cysteine, histidine and tryptophan. 19,15 This has helped split the amino acid series, incorporate amino acid chains and also alter amino acids biochemical structures and causes proteolytic changes in protein compounds. Therefore, tissue damage is being shown in the destruction of protein structures of the tissue and also lipid structures of the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

“…This herbicide, owing to its rapid impact and the simplification of administration, proved to be widely utilized as a test model for studying lung injury, particularly alveolar damages. 19 The study recorded a paraquat distribution of three-dimensional model, indicating paraquat dichloride toxicity and it was expected to make a contribution to variable alterations in the hematological parameters, in which the overall mean erythrocyte count, hemoglobin and packed cell volume throughout the paraquat treatment groups compared to the control group were discovered to be significantly decreased. This discovery demonstrated that paraquat dichloride can cause anemia.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2022

The main objective of the experiment is aimed to examine the impact of paraquat dichloride on the body weights of adult male Wistar rats as well as in their haematological tissues. The total number of male Wistar rats was 48 and was divided into 4 groups of 12 each. The 1 st group (Test 1) served as control. The other three groups served as experimental groups in which the paraquat dichloride was administered. The experimental groups which are 2 nd group (Test 2), 3 rd group (Test 3) and 4 th group (Test 4) received doses of paraquat dichloride of 10 mg/kg b.wt/per oral/day, 20 mg/kg b.wt/per oral/day and 40 mg/kg b.wt/per oral/ day respectively. The experiment was carried out for a time duration of 42 days. The mean values of body weights, erythrocyte indices, total erythrocyte count (TEC), total leucocyte count (TLC) and Hb concentrations were significantly (P<0.05) decreased in Test 2, 3 and 4 rats, excluding packed cell volume (PCV), which in comparison to the control groups. Outcomes and observations from hematological parameters and bone marrow revealed the toxicity of paraquat dichloride to hematological tissues resulting in anemia and bone marrow hypoplasia which eventually leads to failure of the bone marrow and extensively hematopoietic system of adult male Wistar rats following long term exposure and high concentration.

Section: Discussionmentioning

confidence: 99%

Untitled

2022

The main objective of the experiment is aimed to examine the impact of paraquat dichloride on the body weights of adult male Wistar rats as well as in their haematological tissues. The total number of male Wistar rats was 48 and was divided into 4 groups of 12 each. The 1 st group (Test 1) served as control. The other three groups served as experimental groups in which the paraquat dichloride was administered. The experimental groups which are 2 nd group (Test 2), 3 rd group (Test 3) and 4 th group (Test 4) received doses of paraquat dichloride of 10 mg/kg b.wt/per oral/day, 20 mg/kg b.wt/per oral/day and 40 mg/kg b.wt/per oral/ day respectively. The experiment was carried out for a time duration of 42 days. The mean values of body weights, erythrocyte indices, total erythrocyte count (TEC), total leucocyte count (TLC) and Hb concentrations were significantly (P<0.05) decreased in Test 2, 3 and 4 rats, excluding packed cell volume (PCV), which in comparison to the control groups. Outcomes and observations from hematological parameters and bone marrow revealed the toxicity of paraquat dichloride to hematological tissues resulting in anemia and bone marrow hypoplasia which eventually leads to failure of the bone marrow and extensively hematopoietic system of adult male Wistar rats following long term exposure and high concentration.