The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

Abstract

REPORT DOCUMENTATION PAGE ublic reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the lata needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing ,is burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently alid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)2 I. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)kir Force Materiel Command*** HEPB SUPPLEMENTARY NOTES ABSTRACT4ixtures of chemicals represent a concern in all areas of toxicology and a challenge to risk Issessors as most sites with environmental contamination, including Department of Defense sites, involve simultaneous or sequential exposures of multiple chemicals to human or ýcological receptors.A major concern with mixtures is that they may lead to outcomes (health effects) or increased toxicity (synergism) not expected from the risk 'haracterization of individual chemicals at the site.The focus of this literature review is :o examine the principles used to determine toxicity in chemical mixtures risk assessment for luman and ecological receptors at hazardous waste sites.This review provides an overview of 'urrent practices useful to a remedial project manager or risk assessor prior to their first ",hemical mixtures risk assessment. 5.SUBJECTTERMS

A review on arsenic in the environment: contamination, mobility, sources, and exposure

“…Toxicity data are oen unavailable, and evaluated data is not sufficient to verify doseresponse curve and action mode. 248…”