The Traditional Role of Platelets in Hemostasis

Drelich, Douglass A.; Bray, Paul F.

doi:10.5772/60595

Cited by 6 publications

(13 citation statements)

References 36 publications

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Section: Established Mechanisms For Hemostasis and Thrombosismentioning

confidence: 99%

“…It is well established that in primary hemostasis, platelets adhere to the damaged vessel wall at the site of injury 2, 3, 8 . This process occurs through multiple signaling cascades and is highly dependent on glycoproteins (GPs) expressed on the platelet surface 2, 3, 8 . The inhibitory function of the intact endothelium (specifically, the production of prostacyclin and nitric oxide as well as expression of CD39) is decreased upon vessel damage, and extracellular matrix proteins such as collagen are exposed to the circulation 2, 3 .…”

Section: Established Mechanisms For Hemostasis and Thrombosismentioning

confidence: 99%

“…After erythrocytes, platelets are the most prevalent blood component, and they vary in size from 2–5 µm 1 . Once released by their megakaryocytic precursor, platelets enter the bloodstream and circulate for 7–10 days 2, 3 . Platelets are complex cells that contain three distinct types of granules: α-granules, dense or δ-granules, and lysosomes 4, 5 .…”

Section: Introductionmentioning

confidence: 99%

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Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

Koupenova

Clancy

Corkrey

et al. 2018

Circulation Research

735

582

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Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been attributed to their essential role in thrombosis, mediating myocardial infarction, stroke, and venous thromboembolism. Increasing knowledge on the platelets' role in the vasculature has led to many advances in understanding not only how platelets interact with the vessel wall but also how they convey changes in the environment to other circulating cells. In addition to their well-described hemostatic function, platelets are active participants in the immune response to microbial organisms and foreign substances. Although incompletely understood, the immune role of platelets is a delicate balance between its pathogenic response and its regulation of thrombotic and hemostatic functions. Platelets mediate complex vascular homeostasis via specific receptors and granule release, RNA transfer, and mitochondrial secretion that subsequently regulates hemostasis and thrombosis, infection, and innate and adaptive immunity.

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Section: Established Mechanisms For Hemostasis and Thrombosismentioning

confidence: 99%

Section: Established Mechanisms For Hemostasis and Thrombosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

Koupenova

Clancy

Corkrey

et al. 2018

Circulation Research

735

582

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“…The cross-reactions between platelet epitopes and the antibodies' anti-thyroid receptors are significant in the pathogenesis of AITDs. It is possible that the same antithyroid antibodies react with platelet receptors, triggering early activation and damage, thereby intensifying AITD progression (Douglass et al, 2015;Marta et al, 2015). In Graves' Disease, TSH receptor antibodies react with the receptors on the platelet membrane, activating them and initiating thrombocytopenia.…”

Section: Participation Of Blood Platelets In the Development Of Aitdsmentioning

confidence: 99%

The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases

Tomczyńska

Saluk‐Bijak

2018

Acta Biochim Pol

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Autoimmune thyroid diseases include several distinct clinical entities, mainly Graves' disease and Hashimoto's thyroiditis. An incompetent immune response directed against the body's own tissues, and the production of antibodies against specific cell antigens accompanied by chronic inflammation, all occur in autoimmune thyroid diseases. The autoimmune process is induced by genetic and environmental factors that are difficult to identify and generates the development of concomitant diseases in other systems. Leukocyte activation and overproduction of inflammatory mediators, as well as improper levels of thyroid hormones, play an essential role in the chronic course of these diseases. The development of autoimmune thyroid diseases results from the impairment of the regulatory and suppressor functions of T-cells or NK cells and activation of B cells, or from the changes in the number of those cells. Many reports have shown the significant role of platelet-leukocyte interaction in inflammation. Autoantibodies react with target antigens in different kinds of cells, including blood platelets, and autoimmune processes can modulate the mutual cooperation of blood platelets and lymphocytes. The activity of blood platelets and lymphocytes is reciprocally regulated. It has been suggested that blood platelets can influence lymphocyte function by direct contact with receptors, and indirectly via soluble mediators. The interactions of platelet-immune cells (neutrophils, monocytes, lymphocyte and dendritic cells) can have a potent enhancing effect on immune cells functions.

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“…The normal hemostatic function or “classical activation” of platelets has been well established (reviewed in [ 1 , 2 ]). Briefly, we will examine the classic platelet receptors and how they contribute to hemostasis, the cessation of bleeding.…”

Section: Introductionmentioning

confidence: 99%

From Classical to Unconventional: The Immune Receptors Facilitating Platelet Responses to Infection and Inflammation

Gautam

Storad

Filipiak

et al. 2020

Biology

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Platelets have long been recognized for their role in maintaining the balance between hemostasis and thrombosis. While their contributions to blood clotting have been well established, it has been increasingly evident that their roles extend to both innate and adaptive immune functions during infection and inflammation. In this comprehensive review, we describe the various ways in which platelets interact with different microbes and elicit immune responses either directly, or through modulation of leukocyte behaviors.

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The Traditional Role of Platelets in Hemostasis

Cited by 6 publications

References 36 publications

Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases

From Classical to Unconventional: The Immune Receptors Facilitating Platelet Responses to Infection and Inflammation

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