2024
DOI: 10.1101/2024.04.25.591188
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The transcription factor ZNF469 regulates collagen production in liver fibrosis

Sebastian Steinhauser,
David Estoppey,
Dennis P. Buehler
et al.

Abstract: Non-alcoholic fatty liver disease (NAFLD) - characterized by excess accumulation of fat in the liver - now affects one third of the world's population. As NAFLD progresses, extracellular matrix components including collagen accumulate in the liver causing tissue fibrosis, a major determinant of disease severity and mortality. To identify transcriptional regulators of fibrosis, we computationally inferred the activity of transcription factors (TFs) relevant to fibrosis by profiling the matched transcriptomes an… Show more

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