The transdermal performance, pharmacokinetics, and anti-inflammatory pharmacodynamics evaluation of harmine-loaded ethosomes

Jiang, Jizong; Ma, Tingyun; Liuhong, Zhang; Cheng, Xuemei; Wang, Changhong

doi:10.1080/03639045.2019.1706549

Cited by 20 publications

(9 citation statements)

References 20 publications

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“…Gel is a commonly used dosage form for loading the ethosomal system and is usually based on Carbopol (76,(82)(83)(84), or hydroxypropyl methylcellulose (85-87), as gel-forming agents. The pH, viscosity, spreadability, and extrudability of ethosomal gels are among their distinguishing features.…”

Section: Ethosomal Gelsmentioning

confidence: 99%

Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Abubakr

Ibrahem

salah

2023

ERU Research Journal

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Ethosomal system is a lipid vesicular nanocarrier that holds a high concentration of alcohols. This nanocarrier is optimized for the dermal and transdermal delivery of medicinal drugs with various physicochemical features. Since its release in 1996, ethosomes have been subjected to subsequent studies to modify the original formula via the addition of different components, leading to the development of novel ethosomal system types. These new carriers are prepared via a variety of methods and characterized through different parameters, including vesicular size, zeta potential, entrapment efficiency, and skin permeation. The ethosomes efficacy in dermal/transdermal administration is evaluated via clinical studies as well as a wide range of in vivo models.Ethosomal dispersions are frequently incorporated into topical preparations, including gels, patches, and lotions, due to their stability and convenience. This article provides a thorough overview of ethosomal systems from the standpoint of ethosomal types, beginning with classical ethosomes and progressing to binary ethosomes and transethosomes. In addition, this work provides a comprehensive overview of the components of the ethosomal system and their contribution to the final properties of ethosomes, besides highlighting the different methods of preparation and the common dosage forms used as ethosomes' vehicles.

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Section: Ethosomal Gelsmentioning

confidence: 99%

Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Abubakr

Ibrahem

salah

2023

ERU Research Journal

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“…Hence, harmine-loaded ethosomes (HLEs) were fabricated, and the results proved that the HLEs had a 1.5-fold higher enhanced skin deposition than HLLs (harmine-loaded liposomes) and HS (harmine solution). 111 As the anti-inflammatory ingredients eugenol (EUG) and cinnamic (CAH) have high lipophilicity and can be lost via volatilization, the clinical use of them has been impeded. A hyaluronic acid (HA) co-hybridized nanovesicle was designed for the treatment of ulcerative colitis (UC), which entraps EUG and CAH 112 (Fig.…”

Section: Microemulsions (Mes) and Nanoemulsions (Nes)mentioning

confidence: 99%

Nano-traditional Chinese medicine: a promising strategy and its recent advances

et al. 2022

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“…It was found to inhibit NF- κ B activation, which lowered the serum level of IL-1 β , TNF- α , and IL-6 [ 123 ]. Harmine-loaded ethosomes are beneficial for treating inflammation in a rat paw edema induced by carrageenan, potentially inhibiting the expression of inflammatory factors such as PEG-2, TNF- α , IL-1 β , and NO [ 124 ]. Furthermore, it also downregulated TLR4 and nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR), and pyrin domain-containing protein 3 (NLRP3) expression myeloperoxidase activity and MDA production along with the enhancement in the activities of SOD [ 125 ].…”

Section: Promising Plant-derived Alkaloidsmentioning

confidence: 99%

Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases

Aryal

Raut

Bhattarai

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Alkaloids are a type of natural compound possessing different pharmacological activities. Natural products, including alkaloids, which originate from plants, have emerged as potential protective agents against neurodegenerative disorders (NDDs) and chronic inflammations. A wide array of prescription drugs are used against these conditions, however, not free of limitations of potency, side effects, and intolerability. In the context of personalized medicine, further research on alkaloids to unravel novel therapeutic approaches in reducing complications is critical. In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-κB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and β-site amyloid precursor protein activity. In silico ADMET and ProTox-II-related descriptors were calculated to predict the pharmacological properties of 280 alkaloids isolated from traditional medicinal plants towards drug development. Out of which, eight alkaloids such as tetrahydropalmatine, berberine, tetrandrine, aloperine, sinomenine, oxymatrine, harmine, and galantamine are found to be optimal within the categorical range when compared to nicotine. These alkaloids could be exploited as starting materials for novel drug synthesis or, to a lesser extent, manage inflammation and neurodegenerative-related complications.

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The transdermal performance, pharmacokinetics, and anti-inflammatory pharmacodynamics evaluation of harmine-loaded ethosomes

Cited by 20 publications

References 20 publications

Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Ethosomes: a potential nanocarrier for transdermal drug delivery‏

Nano-traditional Chinese medicine: a promising strategy and its recent advances

Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases

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