The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer

Daniels, Tracy R.; Delgado, Tracie; Rodríguez, José Antonio; Helguera, Gustavo; Penichet, Manuel L.

doi:10.1016/j.clim.2006.06.010

Cited by 553 publications

(498 citation statements)

References 99 publications

Supporting

Mentioning

483

Contrasting

Unclassified

Order By: Relevance

“…The transferrin receptor (CD71) is a cell membrane-associated glycoprotein involved in iron homeostasis and cell growth. It has been explored as a target for delivering therapeutic agents into cancer cells, due to its increased expression on malignant cells, accessibility on the cell surface, and constitutive endocytosis (12)(13)(14). CD71 was also used here as it is always expressed in normal mesothelial cells, contributing to further identification and immunophenotyping with the basic panel (15).…”

Section: Discussionmentioning

confidence: 99%

“…CD71 was used as a marker to localize a suspicious CD45 negative cell population, which could be of malignant or other origin. Although it is not a common tumor marker, it is upregulated in proliferating cells (such as tumor cells) (12)(13)(14). It is also expressed by normal mesothelial cells (15), so it could operate as a linkage marker for their differential diagnosis.…”

Section: Flow Cytometric Gating Strategy Initial Panelmentioning

confidence: 99%

See 1 more Smart Citation

An improved flow cytometric assay for detection and discrimination between malignant cells and atypical mesothelial cells, in serous cavity effusions

Kentrou

Tsagarakis

Tzanetou³

et al. 2011

Cytometry Part B Clinical

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Flow Cytometric Gating Strategy Initial Panelmentioning

confidence: 99%

An improved flow cytometric assay for detection and discrimination between malignant cells and atypical mesothelial cells, in serous cavity effusions

Kentrou

Tsagarakis

Tzanetou³

et al. 2011

Cytometry Part B Clinical

View full text Add to dashboard Cite

“…It is rapidly and constitutively endocytosed to an acidic compartment, which is consistent with the pH dependence of arenavirus entry 8 . It is expressed ubiquitously, and at high levels on activated or rapidly dividing cells, including macrophages and activated lymphocytes, major targets of arenaviral infection 20,21 . TfR1 is also highly expressed on endothelial cells 22,23 , which are thought to be central to the pathogenesis of haemorrhagic fever 24 .…”

mentioning

confidence: 99%

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

Radoshitzky

Abraham

Spiropoulou

et al. 2007

Nature

395

425

View full text Add to dashboard Cite

At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old World arenavirus, uses the cellular receptor α-dystroglycan to infect cells 1 . Machupo, Guanarito, Junin and Sabia viruses are New World haemorrhagic fever viruses that do not use α-dystroglycan 2 . Here we show a specific, high-affinity association between transferrin receptor 1 (TfR1) and the entry glycoprotein (GP) of Machupo virus. Expression of human TfR1, but not human transferrin receptor 2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the GP of Machupo, Guanarito and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TfR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin and Sabia viruses, but not that of Lassa virus. Iron depletion of culture medium enhanced, and iron supplementation decreased, the efficiency of infection by Junin and Machupo but not Lassa pseudoviruses. These data indicate that TfR1 is a cellular receptor for New World haemorrhagic fever arenaviruses.Arenaviruses are enveloped, single-stranded, bisegmented RNA viruses 3 . The family Arenaviridae consists of a single genus (Arenavirus), which includes at least 23 recognized viruses 4 . Arenaviruses have been classified into two antigenically and geographically distinct groups, the Lassa-lymphocytic choriomeningitis serocomplex ('Old World arenaviruses') and the Tacaribe serocomplex ('New World arenaviruses'). Five arenaviruses are known to cause acute viral haemorrhagic fever in humans, with case-fatality rates as high as 30%. Lassa virus (LASV) is an Old World arenavirus that causes Lassa fever.

show abstract

“…One of the most abundantly studied protein ligands is the iron transport protein, termed as transferrin (Tf), which has a high affinity for Tf receptors (TfR, also known as CD71) as potential diagnostic targets by enabling endocytosis and internalization into the cellular cytoplasm. [587] In fact TfR is a glycoprotein in charge of mediating the uptake of the iron concentration in biological environments. [498,588] Since TfR are overexpressed both on the endothelial cells of the blood-brain barriers and in solid tumors, it has been extensively used to decorate nanoparticles for achieving brain delivery and actively targeting cancerous tissues.…”

Section: Proteinsmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

View full text Add to dashboard Cite

In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

show abstract

The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer

Cited by 553 publications

References 99 publications

An improved flow cytometric assay for detection and discrimination between malignant cells and atypical mesothelial cells, in serous cavity effusions

An improved flow cytometric assay for detection and discrimination between malignant cells and atypical mesothelial cells, in serous cavity effusions

Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Contact Info

Product

Resources

About