Th e graduates of tertiary education level are one of the risk groups in the economically active age, who have a signifi cant problem to fi nd a job in the labour market. Th e research has been focused on defi ning the key factors infl uencing the creation of competitive advantages of the tertiary education graduates entering labour market as well as to identify the eff ectiveness of these factors in the process of entering the tertiary education graduates in the labour market. Th e methods of analysis were used in the processing of a survey of graduates from three universities of the Czech Republic, namely: the Masaryk University Czech Republic, the Mendel University in Brno, and the Brno University of Technology, at all levels of the higher education degree (Bachelor, Master, PhD) completed by the respondents graduating no earlier than two years ago. Th e data were collected through an online questionnaire, published in the February and March 2013 on the server http://rela.mendelu.cz, at the number of 150 returned fi lled questionnaires. Based on the analysis of secondary sources, there were for the research purposes defi ned fi ve key factors infl uencing the effi ciency of entering the labour market. Th ese factors are the analysis of the current labour market situation and the rational preference of specialization, the active search and participating in programs and the internships focused on gaining the practical experience, the acquisition of professional skills, the use of institutional support and professional assistance and the factor of the building and use of networking.