The Treatment of Cancer Metastases in the Lung by means of Radiating Microspheres*

Im, Ariel; Gt, Pack

doi:10.1055/s-0028-1101262

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Takip eden yıllarda intraarteriyel Y-90 mikroküre uygulamaları başlamış ve hepatik arter yoluyla karaciğer tümörlerinde elde edilen başarılar umut verici olmuştur. Bu araştırmalardan elde edilen veriler sayesinde intraarteriyel Y-90 mikroküre tedavisine olan ilgi artmıştır (10,11,12).…”

Section: Radyoembolizasyonkavramıvetarihiunclassified

Treatment of Intrahepatic Cholangiocellular Carcinoma with Y-90 Labelled Microspheres

Balli¹

2019

nts

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Intrahepatic cholangiocellular carcinoma (ICC) is a rapidly progressive malignancy of intrahepatic bile duct epithelium. ICC is the second most common primary malignant tumor of the liver which accounts for 10% to 20% of primary liver tumors. At the present time, surgery has been accepted as the only potential curative treatment method, however, only 30% of patients are eligible for surgical treatment because of anatomical situations, insufficient liver reserve, or concomitant comorbidities. For ICC patients who are ineligible for surgical treatments, therapies like systemic chemotherapy, thermal or nonthermal ablations, and external radiotherapy are applied as an initial treatment. In addition, less side effects advantage over systemic chemotherapy, yttrium-90 marked microsphere treatment has been prominent especially in the last years. The majority of the recent studies have proved the effectivity of yttrium-90 labelled microsphere treatment in ICC and accepted this treatment as a safe treatment. However, the variability of the patients' demographical features in these studies leads to different outcomes which is thought to be as a result of individual and biological discrepancies.

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Section: Radyoembolizasyonkavramıvetarihiunclassified

Treatment of Intrahepatic Cholangiocellular Carcinoma with Y-90 Labelled Microspheres

Balli¹

2019

nts

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“…Unfortunately, 2 of the patients in the cohort developed significant gastric symptoms from unintentional irradiation of the stomach, which is not surprising given the unsophisticated catheters and angiographic techniques available at the time 9 . Other reports described the use of 90 Y in the treatment of lung cancers, osteogenic sarcomas, and other tumors using plastic and ceramic microspheres with different techniques and, unfortunately, overall poor results 10, 11…”

Section: Radioembolization: Early Experience and Developmentmentioning

confidence: 99%

The development, commercialization, and clinical context of yttrium-90 radiolabeled resin and glass microspheres

Westcott

Coldwell

Liu

et al. 2016

Advances in Radiation Oncology

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Selective internal radiation therapy has emerged as a well-accepted therapeutic for primary and metastatic hepatic malignancies. This therapeutic modality requires the combined efforts of multiple medical disciplines to ensure the safe delivery of yttrium-90 (90Y)-labeled microspheres. The development of this therapy followed decades of clinical research involving tumor vascularity and microsphere development. Today, it is essential that treating physicians have a thorough understanding of hepatic tumor vascularity and 90Y microsphere characteristics before undertaking this complex intervention. This review explores the contributions of early investigators of this therapy, as well as the development, US Food and Drug Administration approval, manufacturing process, and attributes of the 2 commercially available 90Y radiolabeled microsphere device to clarify the key physical differences between the products.

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“…Clinical reports from the early days of RE reported its use in lung and bone tumors [5,6]. First patient series with intravenous application had poor outcomes [7].…”

Section: History Ofmentioning

confidence: 99%

Standards of Practice in Transarterial Radioembolization

Mahnken

Spreafico

Maleux

et al. 2013

Cardiovasc Intervent Radiol

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The Treatment of Cancer Metastases in the Lung by means of Radiating Microspheres*

Cited by 6 publications

References 5 publications

Treatment of Intrahepatic Cholangiocellular Carcinoma with Y-90 Labelled Microspheres

Treatment of Intrahepatic Cholangiocellular Carcinoma with Y-90 Labelled Microspheres

The development, commercialization, and clinical context of yttrium-90 radiolabeled resin and glass microspheres

Standards of Practice in Transarterial Radioembolization

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