The treatment of children with acute lymphoblastic leukemia in Thailand

Laosombat, Vichai; Wongchanchailert, Malai; Sattayasevana, Benjamas; Wiriyasateinkul, Aranya; Watanaarepornchai, Somchai

doi:10.1002/mpo.1321

Cited by 12 publications

(18 citation statements)

References 8 publications

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“…[12][13][14][15] It is noteworthy that, in a study conducted in Honduras of 168 children with ALL between January 1999 and January 2002, the TRM rate was 20.8%, 4 which was higher than our more recent and much larger cohort. Indeed, our results verify that TRM is decreasing over time in Central America; 11.2% of children who were diagnosed before July 1, 2004 experienced TRM versus 7.9% of children who were diagnosed after that date.…”

Section: Discussioncontrasting

confidence: 55%

“…Whereas ALL in HICs has been associated with TRM rates of 1% to 3%, [6][7][8][9][10][11] the few studies that have investigated LICs have identified rates from 11% to 21%. 4,[12][13][14][15] In El Salvador, 12.5% of children with ALL experienced TRM. 16 Although we identified several predictors of overall TRM in the El Salvador cohort, the limited sample size precluded an analysis of the patterns and timing of TRM.…”

mentioning

confidence: 99%

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Treatment‐related mortality in children with acute lymphoblastic leukemia in Central America

Gupta

Antillón²,

Bonilla

et al. 2011

Cancer

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BACKGROUND:The objectives of this study were to describe the incidence, timing, and predictors of treatmentrelated mortality (TRM) among children with acute lymphoblastic leukemia (ALL) in El Salvador, Guatemala, and Honduras. METHODS: Patients aged <20 years who were diagnosed with ALL between January 2000 and March 2008, who received treatment in any of the 3 countries, and who started induction chemotherapy were included in the study. Almost all patients were treated on the El Salvador-Guatemala-Honduras II protocol, which was based on the St. Jude Total XIII and XV protocols. Biologic, socioeconomic, and nutritional variables were examined as predictors of TRM. RESULTS: Of 1670 patients, TRM occurred as a first event in 156 children (9.3%); TRM occurred during remission induction therapy in 92 of 156 children (59%), between remission induction and maintenance therapy in 27 of 156 children (17%), and during maintenance therapy in 37 of 156 children (24%). Although the TRM rate decreased in patients who were diagnosed after July 1, 2004 (11.2% vs 7.9%; P ¼ .02), the rate of induction death did not change (5.2% vs 5.8%; P ¼ .58). Independent predictors of induction death included higher risk ALL (odds ratio [OR], 1.84; 95% confidence interval [CI], 1.03-3.27; P ¼ .04), lower initial platelet counts (OR per 10 Â 10

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Section: Discussioncontrasting

confidence: 55%

mentioning

confidence: 99%

Treatment‐related mortality in children with acute lymphoblastic leukemia in Central America

Gupta

Antillón²,

Bonilla

et al. 2011

Cancer

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“…For patients with CNS disease at diagnosis, cranio-spinal irradiation (CSI) was applied in some protocols. The 5-year event-free survival and overall survival rate of 50 and 66% after ALL therapy in Thailand was reported [9].…”

Section: Methodsmentioning

confidence: 97%

“…The subjects received treatment per individual institutional protocols. Nine institutes used modified CCG-105 and CCG-106 protocols and one used St Jude total XIII A and B protocols [9,10]. Multi-chemotherapeutic agents were mainly used for ALL therapy.…”

Section: Methodsmentioning

confidence: 99%

Late effects in survivors of childhood acute lymphoblastic leukemia: a study from Thai Pediatric Oncology Group

et al. 2010

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Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of long-term late effects. Therefore, systematic screenings of the late complications are essential. The objective of this study was to determine the prevalence of late effects of Thai children and adolescents after completion of ALL therapy. We performed a cross-sectional study for evaluation of the late effects in ALL survivors who came for follow-up at 10 pediatric oncology centers in Thailand. We evaluated the treatment-related late complications of children and adolescents who had finished ALL treatment for at least 2 years. Demographic data, treatment modalities, and late effects were recorded and analyzed. There were 258 survivors with a median age of 12.2 years (range 3.6-23.3 years). The median follow-up time was 7.2 years (range 2-17.5 years). Forty-seven percent (122 cases) suffered from at least one late effect. Overweight/obesity was the most common late effect. Radiation of central nervous system was a significant risk factor for overweight/obesity (OR 1.97, 95% CI 1.02-3.81) and educational problems (OR 4.3, 95% CI 1.32-14.02). Our data have demonstrated a significant prevalence of late effects after childhood ALL therapy. A long-term follow-up program for survivors of childhood cancer is therefore needed in our country.

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“…[1] Compared with children in high-income countries (HIC), children in LMIC are disproportionately affected by treatment-related mortality (TRM), defined as death due to adverse effects of treatment rather than disease progression. [2][3][4][5][6][7][8] In children with acute lymphoblastic leukemia (ALL), TRM has been estimated to be in the range of 11-21% in LMIC, compared with 1-3% in HIC. [2][3][4][5][6][7] As the largest contributor to TRM, infectious complications such as varicella have a greater impact on outcomes and costs of pediatric cancer in LMIC.…”

Section: Introductionmentioning

confidence: 99%

Incidence and consequences of varicella in children treated for cancer in Guatemala

Brown

Asturias

Melgar³

et al. 2016

World J Pediatr

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The treatment of children with acute lymphoblastic leukemia in Thailand

Cited by 12 publications

References 8 publications

Treatment‐related mortality in children with acute lymphoblastic leukemia in Central America

Treatment‐related mortality in children with acute lymphoblastic leukemia in Central America

Late effects in survivors of childhood acute lymphoblastic leukemia: a study from Thai Pediatric Oncology Group

Incidence and consequences of varicella in children treated for cancer in Guatemala

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