The Treatment of Chronic Anal Fissure with Botulinum Toxin

Godevenos, Dimitrios; Pikoulis, Emmanouil; Pavlakis, Emmanouil; Daskalakis, P.; Stathoulopoulos, Athanasios; Gavrielatou, E.; Leppäniemi, Ari

doi:10.1080/00015458.2004.11679618

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Botulinum Toxin1

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2005

2023

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Cited by 8 publications

(2 citation statements)

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“…Pharmacother. (2005) 6(14) a second injection using a higher dose in patients with prior failure of botulinum toxin [46,58,62,63].…”

Section: Botulinum Toxinmentioning

confidence: 99%

Pharmacological advancements in the treatment of chronic anal fissure

Acheson

Scholefield

2005

Expert Opinion on Pharmacotherapy

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Chronic anal fissure is a tear in the lining of the anal canal that, if not treated appropriately at an early stage, causes considerable anal pain during defaecation. Surgery is no longer considered the first-line treatment of this common condition, as recent advancements in medical treatment has produced promising results in the healing of fissures, thus avoiding the unwanted complications that frequently occur following operative treatment. This review looks at those pharmacological agents used commonly in the treatment of chronic anal fissures and explores alternative therapies that may be of benefit in the future.

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“…Pharmacother. (2005) 6(14) a second injection using a higher dose in patients with prior failure of botulinum toxin [46,58,62,63].…”

Section: Botulinum Toxinmentioning

confidence: 99%

Pharmacological advancements in the treatment of chronic anal fissure

Acheson

Scholefield

2005

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…Botulinum toxin A binds with high affinity to cholinergic nerve endings, 3 and selectively inhibits their activity: Btx‐A is currently used in GI spastic disorders as achalasia, 4 anal fissure, 5–7 sphincter of Oddi dysfunction and other dyskinetic diseases (idiopathic gastroparesis) 8 …”

Section: Introductionmentioning

confidence: 99%