The Treatment of Chronic Peptic Ulcer

Objective: The major objective of this present study was to evaluate the neuroprotective effect of fractional flower extracts (acetone, petroleum ether, methanol and aqueous) of Mirabilis jalapa (MJ) against aluminium hydrochloride-induced neurotoxicity in male wister rats. Methods:From the different fractional flower extracts of Mirabilis jalapa (MJ), two doses (250 and 500 mg/kg body weight) of each extract was initially selected and administered per orally 30 min prior to aluminium hydrochloride administration to the different animal groups once a day for a period of 45 d. Rat serum was collected from different animal groups on 1 st , 15 th , 30 th and 45 th Results: On the 9 days for estimation of marker enzymes, where a reduction in marker was observed. Animal was sacrificed by decapitation and the whole brain of rats was analyzed to estimate the levels of nitrite, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (DOS), catalase, reduced glutathione and acetylcholinesterase (AchE).th Conclusion: This result is indicating evidence for Mirabilis jalapa had a significant neuroprotective effect on aluminium hydrochloride-induced neurotoxicity and also supports by histopathological studies.day the Wister rats were sacrificed and cerebral cortex was removed. One-half of the cerebral cortex samples from different groups of Aluminium hydrochloride treated rats were stored in FAM mixture (40% formaldehyde, acetic acid and methanol in the ratio of 1:1:8) for histological analysis. From the study confirmed that dose of 250 and 500 mg/kg bwt of methanolic extract of MJ significantly (p˂0.001) increases the reduced glutathione, superoxide dismutase and catalase level, whereas petroleum ether, acetone and aqueous fractional flower extracts of MJ significantly (p˂0.01) decreases nitrite, TBARS and AchE levels of aluminium hydrochloride treated groups.

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“…These are made by acute toxic class method [9]. In this, stepwise procedures with three animals of the same sex were taken.…”

Section: Experimental Designmentioning

confidence: 99%

Neuroprotective Activity of Fractional Flower Extracts of Mirabilis Jalapa Against Aluminium Hydrochloride Induced Neurotoxicity in Male Wister Rats

Babu

Swain

Renuka

2017

Int J Pharm Pharm Sci

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“…19 In his gem of a book in 1982, Douglas W. Piper wrote about the mysterious condition. 20 He stated that '. .…”

Section: Historical Perspectivesmentioning

confidence: 99%

Whither dyspepsia? A historical perspective of functional dyspepsia, and concepts of pathogenesis and therapy in 2009

Talley

Choung

2009

J of Gastro and Hepatol

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Functional dyspepsia is a highly prevalent but heterogeneous disorder; multiple pathogenetic mechanisms are likely involved but the underlying causal pathways in functional dyspepsia remain obscure. The term functional dyspepsia was popularized by the famed Walter Alvarez at the Mayo Clinic early last century. Prominent Australian gastroenterologists who have contributed to our understanding of functional dyspepsia include Peter Baume, Barry Marshall, Douglas Piper, Nick Talley, John Kellow, and Gerald Holtmann. Specific dyspeptic symptoms have not generally correlated very well with any particular physiologic disturbance, although gastric disaccommodation and duodenal eosinophilia have been linked to early satiety in this condition. Genetic markers have been tentatively identified, and functional dyspepsia can follow bacterial gastroenteritis. No objective diagnostic tools for functional dyspepsia are currently agreed upon, although meal induction of symptoms appears reproducible and may have diagnostic utility. The symptomatic criteria for functional dyspepsia (Rome III criteria) are based on expert consensus and the exclusion of organic causes. Various therapeutic modalities for functional dyspepsia have been explored; however, empirical approaches are still employed for the treatment of functional dyspepsia. Better approaches for functional dyspepsia are likely to follow an improved understanding of the underlying pathophysiological abnormalities.

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“…Το σύστημα αυτό χρησιμοποιείται και στον διαχωρισμό γλυκεριναιδερικών λιποειδών ανάλογα με το μήκος της αλυσίδας του γλυκερυναιδερικού δεσμού (Hanahan και συν., 1981) καδώς και στον διαχωρισμό φωσφο και φωσφονολιποειδών (Demopoulos και συν., 1981) Σε χρωματογραφία στήλης πυριτικού οξέος η AGEPC εκλύεται σχεδόν αποκλειστικά με το μίγμα χλωροφορμίουμεδανόλης 1:4 ν/ν. (Packham, 1977-Chignard, Benveviste, 1977,1980.…”

Section: εισαγωγηunclassified

“…Παρόμοιες βλάβες διεπιστώθησαν σε ασθενείς που ελάμβαναν σαλικυλικά per os και η αιμορραγία ανωτέρου πεπτικού καταλαμβάνει uy^n θέση σε συχνότητα σε ασθενείς που ελάμβαναν ασπιρίνη. (Silvoso, 1979-Piper, 1980. Δεν υπάρχει ένδειξη αυξημένης συχνότητας έλκους του δωδεκαδάκτυλου σε ασθενείς που λαμβάνουν σαλικυλικά.…”

Section: εισαγωγηunclassified

“…Επίσης έχει αναφερθεί ότι οι προσταγλανδίνες διεγείρουν την μεταφορά του νατρίου και τον σχηματισμό του κυκλικού AMP. (Robert, 1979 (Piper, 1980). Επιπρόσθετα υπάρχει θετικός συσχετισμός μεταξύ του αριθμού των καπνιζομένων σιγαρέττων και της επιμονής του έλκους (Friedman, 1974).…”

Section: εισαγωγηunclassified

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Μελετη Των Επιπεδων Του Παραγοντα Ενεργοποιησης Αιμοπεταλιων (Paf) Σε Βιολογικαυγρα Ασθενων Με Γαστρορραγια

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The Treatment of Chronic Peptic Ulcer

Cited by 4 publications

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Neuroprotective Activity of Fractional Flower Extracts of Mirabilis Jalapa Against Aluminium Hydrochloride Induced Neurotoxicity in Male Wister Rats

Neuroprotective Activity of Fractional Flower Extracts of Mirabilis Jalapa Against Aluminium Hydrochloride Induced Neurotoxicity in Male Wister Rats

Whither dyspepsia? A historical perspective of functional dyspepsia, and concepts of pathogenesis and therapy in 2009

Μελετη Των Επιπεδων Του Παραγοντα Ενεργοποιησης Αιμοπεταλιων (Paf) Σε Βιολογικαυγρα Ασθενων Με Γαστρορραγια

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