The treatment of deep frostbite with hyperbaric oxygen

Ay, Hakan; Yıldız, Şenol; Uzun, Günalp; Solmazgül, Emrullah; Dündar, Kadir; Yıldırım, İsmail Okan

doi:10.1016/j.injury.2005.04.015

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Operations lead to adverse consequences because healthy and necrotic tissues of patients with frostbite are difficult to distinguish . Hyperbaric oxygen therapy for frostbite is also complex and expensive; this treatment also lacks comparative studies . Thus far, few methods have successfully treated cold injuries.…”

mentioning

confidence: 99%

Effects of low‐frequency pulsed electromagnetic fields on plateau frostbite healing in rats

Jiao

Lin²,

Jiao³

et al. 2016

Wound Repair Regeneration

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Plateau frostbite (PF) treatments have remained a clinical challenge because this condition injures tissues in deep layers and affected tissues exhibit unique pathological characteristics. For instance, low-frequency pulsed electromagnetic field (PEMF) can affect tissue restoration and penetrate tissues. Therefore, the effect of PEMF on PF healing should be investigated. This study aimed to evaluate the effects of low-frequency PEMF on PF healing systematically. Ninety-six Sprague-Dawley rats were randomly and equally divided into three groups: normal control, partial thickness plateau frostbite (PTPF), and PTPF with low-frequency PEMF exposure (PTPF + PEMF). PTPF wounds were induced in the dorsum of the rats. The PTPF + PEMF group was exposed to low-frequency PEMF daily. During PF healing, wound microcirculation in each group was monitored through contrast ultrasonography. Wound appearance, histological observation, and wound tensile strength were also evaluated. Results showed that the rate of the microcirculation restoration of the PTPF + PEMF group was nearly 25% faster than that of the PTPF group, and wound appearance suggested that the healing of the PTPF group was slower than that of the PTPF + PEMF group. Histological observation revealed that PEMF accelerated the growth of different deep tissues, as confirmed by tensile strength examination. Low-frequency PEMF could penetrate PF tissues, promote their restoration, and provide a beneficial effect on PF healing. Therefore, this technique may be a potential alternative to treat PF.

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mentioning

confidence: 99%

Effects of low‐frequency pulsed electromagnetic fields on plateau frostbite healing in rats

Jiao

Lin²,

Jiao³

et al. 2016

Wound Repair Regeneration

View full text Add to dashboard Cite

show abstract

“…Cold and tissue hypoxia have been proven to be the main causes of frostbite injuries. [23][24][25][26] However, the pathophysiologic changes of HAF caused by combined cold and hypoxia have not been described. Therefore, we improved the HAF models and evaluated the pathophysiologic process of HAF tissue under high altitude environment simulation in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…5 ,23,24 Hypoxia and cold cause increases in blood packed-cell volume, viscosity, and small vessel blockage, which are the main contributors to frostbite injuries. 25,26 Therefore, more suitable frostbite models and pathophysiologic determination should be implemented to elucidate clearly and completely high altitude frostbite (HAF) pathophysiology and obtain suitable reference for clinical practical application.…”

Section: Introductionmentioning

confidence: 99%