The treatment of depression in cancer patients: a systematic review

Rodin, Gary; Lloyd, Nancy; Katz, Mark R.; Green, Esther; Mackay, Jean A.; Wong, Rebecca

doi:10.1007/s00520-006-0145-3

Cited by 186 publications

(157 citation statements)

References 59 publications

(181 reference statements)

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“…O número de estudos de intervenção, avaliando o uso de antidepressivos em pacientes com câncer, tem aumentado [38][39][40] . As evidências disponíveis sugerem fortemente que a depressão em pacientes com câncer responde aos antidepressivos tricíclicos (TCA), aos inibidores seletivos da recaptura de serotonina (ISRS), à mirtazapina e à mianserina 38 .…”

Section: Suicídiounclassified

“…A mianserina, um tetracíclico, foi efetiva na redução de sintomas depressivos. A terapia cognitivocomportamental e os grupos de suporte foram efetivos na redução de sintomas depressivos 39 .…”

Section: Suicídiounclassified

“…Rodin et al 39 também realizaram uma revisão sistemá-tica para avaliar a eficácia de tratamentos farmacológicos e não farmacológicos no tratamento da depressão em pacientes com câncer. Nessa revisão, foram incluídos apenas sete estudos com tratamentos farmacológicos e quatro estudos com terapias não farmacológicas.…”

Section: Suicídiounclassified

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Depressão e câncer

Bottino¹,

Fráguas

Gattaz

2009

Rev. psiquiatr. clín.

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ResumoA depressão é o transtorno psiquiátrico mais comum em pacientes com câncer, com prevalências variando de 22% a 29%. Essa variabilidade está associada a sítios do tumor, estágio clínico, dor, funcionamento físico limitado, além da existência de suporte social. A depressão associa-se a um pior prognóstico e aumento da mortalidade pelo câncer. Síndromes depressivas podem ser uma consequência das terapias antineoplásicas, como ocorre em 21% a 58% dos pacientes recebendo interferon-alfa. Sentimentos de tristeza e desespero podem inibir a procura de cuidado pelos pacientes, dificultando o reconhecimento da depressão. O tratamento com antidepressivos é efetivo e melhora a adesão aos tratamentos do câncer, reduzindo efeitos adversos como náusea, dor e fadiga. Em pacientes com câncer, tratamento prévio com antidepressivos pode minimizar sintomas depressivos induzidos por interferon-alfa. O tratamento com antidepressivos parece ser uma estratégia efetiva para prevenir o desenvolvimento da depressão induzida por interferon-alfa. Intervenções psicossociais, como técnicas de relaxamento, terapia individual e em grupo, também podem ser utilizadas na redução dos sintomas depressivos e de estresse em pacientes com câncer. Bottino SMB, et al. / Rev Psiq Clín. 2009;36(3):109-15Palavras-chave: Depressão, câncer, diagnóstico, tratamento. AbstractDepression is the most common psychiatric disorder in patients with cancer, with prevalence rates ranging from 22% to 29%. This variability is associated to cancer sites, clinical stages, pain, limited physical functioning, beyond the existence of social support. Depression is associated to poorer prognosis and higher cancer mortality. Depressive syndromes can be a consequence of the antineoplasic therapies, as occurs in 21% to 58% of the patients treated with alfa-interferon. Sadness and desperation can inhibit the search for care by the patients, and difficult depression recognition. Antidepressant treatment is effective, and improve the adherence to cancer treatments, reducing side effects as nausea, pain and fatigue. In cancer patients, pretreatment with antidepressants seems to minimize depressive symptoms induced by interferon-alfa. Psychosocial interventions as relaxing techniques, group and individual psychotherapies can also be applied to reduce depressive and stress symptoms in patients with cancer.Bottino SMB, et al. / Rev Psiq Clín. 2009;36(3):109-15

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Section: Suicídiounclassified

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Depressão e câncer

Bottino¹,

Fráguas

Gattaz

2009

Rev. psiquiatr. clín.

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“…While most patients adjusted well, in their sample of 74 women, those with lower socioeconomic status and those without family support or religious belief suffered more often from adjustment disorders [66]. Furthermore, pain, health-related QoL and poor performance status have been shown to affect these psychological disorders [67,68].…”

Section: Anxiety and Depressionmentioning

confidence: 95%

Supportive care for women with gynecologic cancers

Chase¹,

Monk²,

Wenzel³

et al. 2008

Expert Review of Anticancer Therapy

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“…Once a diagnosis of depression is made, ANZSPM clinicians, similar to those in the UK 27 and other countries, 31 prefer to treat with both pharmacological and non-pharmacological interventions.…”

Section: Treatmentmentioning

confidence: 99%

Depression in palliative care patients: a survey of assessment and treatment practices of Australian and New Zealand palliative care specialists

Porche¹,

Reymond

Callaghan

et al. 2014

Aust. Health Review

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Objective. To explore the practices of members of the Australian and New Zealand Society of Palliative Medicine (ANZSPM) in assessing and treating depression in palliative care patients.Methods. Semistructured questionnaires were forwarded to ANZSPM members in consecutive mail-outs to survey diagnostic and treatment practices for depression.Results. The response rate was 62.3%. The median prevalence of depression, as perceived by respondents, in the present respondent patient populations was 20% (range 0%-90%); 57.1% of respondents always assessed for depression, whereas 42.9% assessed for depression sometimes. The majority (98.9%) of respondents relied on clinical interviews to assess depression; non-somatic symptoms of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria were more useful than somatic symptoms. The depression screening tools most frequently used were one-and twoitem questions. Pharmacological and non-pharmacological methods were used to treat depression, with selective serotonin reuptake inhibitors the most frequently prescribed medications. Psycho-educational and supportive counselling were the most frequently used non-pharmacological interventions. Nominated measures to augment depression management included improving access to psychiatry, psychology and other allied health services, the development of a screening tool specific to palliative care patients and associated guidelines for depression management.Conclusions. This is the first Australasian study to explore the practice of medical practitioners regarding depression in palliative patients. Incorporation of screening tool questions into palliative care assessment interviews may warrant future research.What is known about the topic? Depression in palliative care patients has a negative impact on quality of life; however, little is known about how Australasian palliative care medical practitioners manage depression in this patient population. What does this paper add? To the researchers' knowledge, this is the first Australasian study that explores the practices of local palliative care specialists in the management of depression in palliative patients. What are the implications for practitioners? Overall management of depression in palliative care populations by Australasian practitioners is similar to that of their European colleagues. Consensus is that for assessment of depression in palliative patients, non-somatic symptoms of DSM-IV criteria are more useful than somatic symptoms. Practitioners report the need for improved access to psychiatric, psychological and other support services, for a palliative care-specific depression screening tool and for depression management guidelines applicable to palliative care patients.

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The treatment of depression in cancer patients: a systematic review

Cited by 186 publications

References 59 publications

Depressão e câncer

Depressão e câncer

Supportive care for women with gynecologic cancers

Depression in palliative care patients: a survey of assessment and treatment practices of Australian and New Zealand palliative care specialists

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