The Treatment of Filariasis Bancrofti With 1‐diethylcarbamyl‐4‐methylpiperazine Hydrochloride (Hetrazan)

The ultrastructure of infective larvae (L3) of Wuchereria bancrofti after treatment with diethylcarbamazine

“…The anti-filarial drug diethylcarbamazine citrate (DEC) has been in clinical use for more than 50 years since the description of its therapeutic efficacy Santiago-Stevenson et al, 1947). However, its pharmacological mechanism of action remains a matter of controversy.…”

Antiparasite Chemotherapy

“…Shortly after this observation DEC was applied and found to be successful in the treat ment of Bancroftian filariasis (7,8). Wilson (9) subsequently confirmed that the drug was equally effective against Brugia malayi.…”

Potential Value of Triple Drug Therapy with Ivermectin, Diethylcarbamazine, and Albendazole (IDA) to Accelerate Elimination of Lymphatic Filariasis and Onchocerciasis in Africa

“…Diethylcarbamazine (N, N-diethyl-4-methyl-1-piperazine carboxamide) was shown to be effective against filarial parasites in the late 1940s [12–15]. Although it was recognized early that DEC can cause adverse reactions in individuals infected with O .…”