The treatment of hyposmia with intranasal steroids

Golding-Wood, David; Holmström, Mats; Darby, Y.; Scadding, Glenis K.; Lund, Valerie J.

doi:10.1017/s0022215100132967

Cited by 59 publications

(28 citation statements)

References 17 publications

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“…Topical steroids have been previously shown to improve the sense of smell in hyposmic allergic patients [14,15] , thus it is unlikely that they are causing olfactory dysfunction in our subjects. Instead, patients with more severe rhinitis may be more likely to pursue treatment with steroid sprays.…”

Section: Discussionmentioning

confidence: 83%

Olfactory Dysfunction in Allergic Rhinitis

Guss

Doghramji

Reger

et al. 2009

ORL

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Background: Olfactory dysfunction in patients with allergic rhinitis has long been thought to be secondary to coexisting chronic rhinosinusitis and polyposis with obstruction of airflow over the olfactory epithelium. Recent evidence suggests that the allergic inflammatory infiltrate may itself affect olfaction in the absence of mucosal hypertrophy. Objective: We undertook a study to determine olfactory function in patients with allergic rhinitis in the presence and absence of chronic sinusitis. Methods: Fifty-one subjects with symptoms of rhinitis who presented for allergy testing were administered the University of Pennsylvania Smell Identification Test. In addition each patient underwent computed tomography (CT) scanning of the sinuses. Results: Eighty percent of subjects were allergic. Subjects with allergic rhinitis and no evidence of sinusitis scored on average in the 30th percentile (95% CI 20–40th percentile) on objective olfactory testing compared to age- and gender-specific norms. Half the allergic patients were classified as normosmic, while half had some degree of hyposmia. Conclusions: Our study demonstrates that even in the absence of mucosal disease on CT scan, a significant subset of patients with allergic rhinitis will exhibit hyposmia, mostly to a mild or moderate degree. The pathophysiology and potential treatments for olfactory loss in these patients should be further explored.

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Section: Discussionmentioning

confidence: 83%

Olfactory Dysfunction in Allergic Rhinitis

Guss

Doghramji

Reger

et al. 2009

ORL

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“…Study characteristics are presented in Table IV. 50,55,[73][74][75][76] In summary, although study results are conflicting, there is evidence, however limited, that topical steroids improve specific measures of olfactory function, especially in patients with seasonal AR. …”

Section: Topical Steroidsmentioning

confidence: 99%

Olfaction in allergic rhinitis: A systematic review

Stuck

Hummel

2015

Journal of Allergy and Clinical Immunology

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“…In 1996, Golding-Wood et al [38] evaluated the efficacy of topical steroid treatment in patients with rhinitis. Twenty-five patients with perennial rhinitis were included in the study, 15 of which initially expressed a weak sense of smell as a significant symptom.…”

Section: Medical Treatment Of Olfactory Dysfunction In Chronic Rhinosmentioning

confidence: 99%

Chronic Rhinosinusitis and Olfactory Dysfunction

Raviv

Kern²

2006

Taste and Smell

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Chronic rhinosinusitis encompasses a group of disorders characterized by inflammation of the mucosa of the nose and paranasal sinuses of at least 12 weeks' duration. In addition to nasal obstruction and discharge, chronic sinusitis is a common cause of olfactory dysfunction. However, smell loss is often overlooked in the clinical setting of sinusitis, with attention instead focused on the respiratory complaints of nasal obstruction, hypersecretion, and facial pressure and pain. Olfactory dysfunction can result in problems including safety concern, hygiene matters, appetite disorders, and changes in emotional and sexual behavior. Although smell loss related to sinonasal disease is probably the most treatable form of olfactory dysfunction, most studies show that improved olfactory sensation in this setting is usually transient and incomplete.

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The treatment of hyposmia with intranasal steroids

Cited by 59 publications

References 17 publications

Olfactory Dysfunction in Allergic Rhinitis

Olfactory Dysfunction in Allergic Rhinitis

Olfaction in allergic rhinitis: A systematic review

Chronic Rhinosinusitis and Olfactory Dysfunction

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