The treatment of late-onset hypogonadism

Üçer, Oktay; Gümüş, Bilal

doi:10.5152/tud.2013.97752

Cited by 8 publications

(4 citation statements)

References 67 publications

(82 reference statements)

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“…Late-onset hypogonadism (LOH) is a common disorder in older men, but it is often underdiagnosed and untreated 22 , 23 . After examining testosterone, we assessed the AMS and found no change in the AMS level.…”

Section: Discussionmentioning

confidence: 99%

Long-term safety, health and mental status in men with vasectomy

Zhao

Kong

et al. 2018

Sci Rep

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Vasectomy is an efficient male contraceptive method, but the long-term effects of this technology in a large population are unclear. To investigate the influence of vasectomy on long-term health effects, we recruited 485 men with a vasectomy and 1940 men without vasectomy in China. After obtaining basic information from the Aging Males’ Symptoms (AMS) scale and other questionnaires, peripheral blood was drawn to assess the hormone levels, prostate specific antigen (PSA) and blood biochemistry. Using multiple linear regression analysis, these factors had no relationship with vasectomy except for four factors including the Somatic score (0.31, 0.02 and 0.61) in AMS, SF-36 score (−18.8, −32.00 and −5.60), “Role emotional” (−6.28, −10.34 and −2.22) and “Mental health” (−1.55, −3.08 and −0.02). A stratified analysis showed that with increased age, smoking and drinking, residence in township or a higher level of education, the mental health of men was worse. Vasectomy had no long-term effect on the level of sexual hormones in men, and it did not increase the level of PSA. The impact of the vasectomy on quality of life in men were mainly reflected in psychological effects, which suggests that men with vasectomy groups many benefit from professional psychological counseling.

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Section: Discussionmentioning

confidence: 99%

Long-term safety, health and mental status in men with vasectomy

Zhao

Kong

et al. 2018

Sci Rep

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“…The cause of the lower decrease in total testosterone compared to bioactive or free testosterone is considered to be the increase in sex hormone-binding globulin with ageing. Hypogonadism prevalence was reported as ranging at 2%-30% between the ages of 40 and 59 and as 20%-45% between the ages of 60 and 69 and gradually increases with age (Huhtaniemi, 2014;Nieschlag et al, 2005;Üçer & Gümüş, 2014). Provision of a treatment to replace missing testosterone is suggested in symptomatic individuals with a total testosterone level below 346 ng/dl (12 nM) (Kim & Moon, 2011;Wang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Efficiency of intracavernosal alprostadil and oral clomiphene citrate combination treatment in penile vasculogenic erectile dysfunction patients accompanied by late‐onset hypogonadism

et al. 2020

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Erectile dysfunction (ED) refers to difficulty in starting and maintaining an adequate erection for satisfactory sexual performance and the stability of this condition (Burnett et al., 2018). The estimated prevalence of ED in men > 40 years of age is almost 50% (Bella, Lee, Carrier, Benard, & Brock, 2015). Different therapeutic agents have been developed for ED treatment, and their effect mechanism depends on the understanding of erection physiology. In ED treatment-resistant patients, lifestyle changes as a first-line treatment option and phosphodiesterase type 5 inhibitors (PDE5 inhibitors) as a second-line treatment option are used. PDE-5 inhibitors are noninvasive, generally well tolerated and efficient in most males. Intracavernosal injections (ICUs), such as alprostadil and papaverine, can be used in 25%-50% of patients who are irresponsive to the treatment and who contraindicate PDE5 inhibitors (Bella et al., 2015; Hatzimouratidis et al., 2019).

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“…According to the guidelines of the International Consultation for Sexual Medicine (ICSM), TRT is advisable when the level of total testosterone is <12 nmol/L or higher, based on clinical judgment [ 281 ] and/or in the presence of LOH symptoms, with these criteria being consistent across various countries. Testosterone is administered in the body through oral, buccal, intramuscular, subcutaneous, and transdermal routes [ 282 , 283 ]. Testosterone treatment, along with a lifelong physical exercise regimen, produces beneficial cardiovascular effects [ 284 ] and may help to maintain the normal level of testosterone in older men [ 285 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

et al. 2021

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Hypogonadism is an endocrine disorder characterized by inadequate serum testosterone production by the Leydig cells of the testis. It is triggered by alterations in the hypothalamic–pituitary–gonadal axis. Erectile dysfunction (ED) is another common disorder in men that involves an alteration in erectile response–organic, relational, or psychological. The incidence of hypogonadism and ED is common in men aged over 40 years. Hypogonadism (including late-onset hypogonadism) and ED may be linked to several environmental factors-induced oxidative stresses. The factors mainly include exposure to pesticides, radiation, air pollution, heavy metals and other endocrine-disrupting chemicals. These environmental risk factors may induce oxidative stress and lead to hormonal dysfunctions. To better understand the subject, the study used many keywords, including “hypogonadism”, “late-onset hypogonadism”, “testosterone”, “erectile dysfunction”, “reactive oxygen species”, “oxidative stress”, and “environmental pollution” in major online databases, such as SCOPUS and PUBMED to extract relevant scientific information. Based on these parameters, this review summarizes a comprehensive insight into the important environmental issues that may have a direct or indirect association with hypogonadism and ED in men. The study concludes that environmental factors-induced oxidative stress may cause infertility in men. The hypothesis and outcomes were reviewed critically, and the mechanistic approaches are applied through oxidant-sensitive pathways. This study also provides reccomendations on future therapeutic interventions and protective measures against such adverse environmental factors-induced hypogonadism and ED.

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The treatment of late-onset hypogonadism

Cited by 8 publications

References 67 publications

Long-term safety, health and mental status in men with vasectomy

Long-term safety, health and mental status in men with vasectomy

Efficiency of intracavernosal alprostadil and oral clomiphene citrate combination treatment in penile vasculogenic erectile dysfunction patients accompanied by late‐onset hypogonadism

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

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